Vacuolar protein sorting-associated protein 26A (Vesicle protein sorting 26A) (hVPS26)
1_MSFLG 6_ GFFGP 11_ ICEID 16_ IVLND 21_ GETRK 26_ MAEMK 31_ TEDGK 36_ VEKHY 41_ LFYDG 46_ ESVSG 51_ KVNLA 56_ FKQPG 61_ KRLEH 66_ QGIRI 71_ EFVGQ 76_ IELFN 81_ DKSNT 86_ HEFVN 91_ LVKEL 96_ ALPGE 101_ LTQSR 106_ SYDFE 111_ FMQVE 116_ KPYES 121_ YIGAN 126_ VRLRY 131_ FLKVT 136_ IVRRL 141_ TDLVK 146_ EYDLI 151_ VHQLA 156_ TYPDV 161_ NNSIK 166_ MEVGI 171_ EDCLH 176_ IEFEY 181_ NKSKY 186_ HLKDV 191_ IVGKI 196_ YFLLV 201_ RIKIQ 206_ HMELQ 211_ LIKKE 216_ ITGIG 221_ PSTTT 226_ ETETI 231_ AKYEI 236_ MDGAP 241_ VKGES 246_ IPIRL 251_ FLAGY 256_ DPTPT 261_ MRDVN 266_ KKFSV 271_ RYFLN 276_ LVLVD 281_ EEDRR 286_ YFKQQ 291_ EIILW 296_ RKAPE 301_ KLRKQ 306_ RTNFH 311_ QRFES 316_ PESQA 321_SAEQP
1: Acts as a component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins (Probable). The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5 (Probable). Required for retrograde transport of lysosomal enzyme receptor IGF2R (PubMed:15078902, PubMed:15078903). Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA) (PubMed:15247922). Required for the endosomal localization of WASHC2A (indicative for the WASH complex) (PubMed:22070227). Required for the endosomal localization of TBC1D5 (PubMed:20923837). Mediates retromer cargo recognition of SORL1 and is involved in trafficking of SORL1 implicated in sorting and processing of APP (PubMed:22279231). Involved in retromer-independent lysosomal sorting of F2R (PubMed:16407403). Involved in recycling of ADRB2 (PubMed:21602791). Enhances the affinity of SNX27 for PDZ-binding motifs in cargo proteins (By similarity)