Transcription factor Maf (Proto-oncogene c-Maf) (V-maf musculoaponeurotic fibrosarcoma oncogene homolog)
1_MASEL 6_ AMSNS 11_ DLPTS 16_ PLAME 21_ YVNDF 26_ DLMKF 31_ EVKKE 36_ PVETD 41_ RIISQ 46_ CGRLI 51_ AGGSL 56_ SSTPM 61_ STPCS 66_ SVPPS 71_ PSFSA 76_ PSPGS 81_ GSEQK 86_ AHLED 91_ YYWMT 96_ GYPQQ 101_ LNPEA 106_ LGFSP 111_ EDAVE 116_ ALISN 121_ SHQLQ 126_ GGFDG 131_ YARGA 136_ QQLAA 141_ AAGAG 146_ AGASL 151_ GGSGE 156_ EMGPA 161_ AAVVS 166_ AVIAA 171_ AAAQS 176_ GAGPH 181_ YHHHH 186_ HHAAG 191_ HHHHP 196_ TAGAP 201_ GAAGS 206_ AAASA 211_ GGAGG 216_ AGGGG 221_ PASAG 226_ GGGGG 231_ GGGGG 236_ GGGAA 241_ GAGGA 246_ LHPHH 251_ AAGGL 256_ HFDDR 261_ FSDEQ 266_ LVTMS 271_ VRELN 276_ RQLRG 281_ VSKEE 286_ VIRLK 291_ QKRRT 296_ LKNRG 301_ YAQSC 306_ RFKRV 311_ QQRHV 316_ LESEK 321_ NQLLQ 326_ QVDHL 331_ KQEIS 336_ RLVRE 341_ RDAYK 346_ EKYEK 351_ LVSSG 356_ FRENG 361_ SSSDN 366_PSSPE
1: Acts as a transcriptional activator or repressor. Involved in embryonic lens fiber cell development. Recruits the transcriptional coactivators CREBBP and/or EP300 to crystallin promoters leading to up-regulation of crystallin gene during lens fiber cell differentiation. Activates the expression of IL4 in T helper 2 (Th2) cells. Increases T-cell susceptibility to apoptosis by interacting with MYB and decreasing BCL2 expression. Together with PAX6, transactivates strongly the glucagon gene promoter through the G1 element. Activates transcription of the CD13 proximal promoter in endothelial cells. Represses transcription of the CD13 promoter in early stages of myelopoiesis by affecting the ETS1 and MYB cooperative interaction. Involved in the initial chondrocyte terminal differentiation and the disappearance of hypertrophic chondrocytes during endochondral bone development. Binds to the sequence 5'-[GT]G[GC]N[GT]NCTCAGNN-3' in the L7 promoter. Binds to the T-MARE (Maf response element) sites of lens-specific alpha- and beta-crystallin gene promoters. Binds element G1 on the glucagon promoter. Binds an AT-rich region adjacent to the TGC motif (atypical Maf response element) in the CD13 proximal promoter in endothelial cells (By similarity). When overexpressed, represses anti-oxidant response element (ARE)-mediated transcription. Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Binds to the ARE sites of detoxifying enzyme gene promoters