Mediator of RNA polymerase II transcription subunit 24 (Activator-recruited cofactor 100 kDa component) (ARC100) (Cofactor required for Sp1 transcriptional activation subunit 4) (CRSP complex subunit 4) (Mediator complex subunit 24) (Thyroid hormone receptor-associated protein 4) (Thyroid hormone receptor-associated protein complex 100 kDa component) (Trap100) (hTRAP100) (Vitamin D3 receptor-interacting protein complex 100 kDa component) (DRIP100)
1_MKVVN 6_ LKQAI 11_ LQAWK 16_ ERWSD 21_ YQWAI 26_ NMKKF 31_ FPKGA 36_ TWDIL 41_ NLADA 46_ LLEQA 51_ MIGPS 56_ PNPLI 61_ LSYLK 66_ YAISS 71_ QMVSY 76_ SSVLT 81_ AISKF 86_ DDFSR 91_ DLCVQ 96_ ALLDI 101_ MDMFC 106_ DRLSC 111_ HGKAE 116_ ECIGL 121_ CRALL 126_ SALHW 131_ LLRCT 136_ AASAE 141_ RLREG 146_ LEAGT 151_ PAAGE 156_ KQLAM 161_ CLQRL 166_ EKTLS 171_ STKNR 176_ ALLHI 181_ AKLEE 186_ ASSWT 191_ AIEHS 196_ LLKLG 201_ EILAN 206_ LSNPQ 211_ LRSQA 216_ EQCGT 221_ LIRSI 226_ PTMLS 231_ VHAEQ 236_ MHKTG 241_ FPTVH 246_ AVILL 251_ EGTMN 256_ LTGET 261_ QSLVE 266_ QLTMV 271_ KRMQH 276_ IPTPL 281_ FVLEI 286_ WKACF 291_ VGLIE 296_ SPEGT 301_ EELKW 306_ TAFTF 311_ LKIPQ 316_ VLVKL 321_ KKYSH 326_ GDKDF 331_ TEDVN 336_ CAFEF 341_ LLKLT 346_ PLLDK 351_ ADQRC 356_ NCDCT 361_ NFLLQ 366_ ECGKQ 371_ GLLSE 376_ ASVNN 381_ LMAKR 386_ KADRE 391_ HAPQQ 396_ KSGEN 401_ ANIQP 406_ NIQLI 411_ LRAEP 416_ TVTNI 421_ LKTMD 426_ ADHSK 431_ SPEGL 436_ LGVLG 441_ HMLSG 446_ KSLDL 451_ LLAAA 456_ AATGK 461_ LKSFA 466_ RKFIN 471_ LNEFT 476_ TYGSE 481_ ESTKP 486_ ASVRA 491_ LLFDI 496_ SFLML 501_ CHVAQ 506_ TYGSE 511_ VILSE 516_ SRTGA 521_ EVPFF 526_ ETWMQ 531_ TCMPE 536_ EGKIL 541_ NPDHP 546_ CFRPD 551_ STKVE 556_ SLVAL 561_ LNNSS 566_ EMKLV 571_ QMKWH 576_ EACLS 581_ ISAAI 586_ LEILN 591_ AWENG 596_ VLAFE 601_ SIQKI 606_ TDNIK 611_ GKVCS 616_ LAVCA 621_ VAWLV 626_ AHVRM 631_ LGLDE 636_ REKSL 641_ QMIRQ 646_ LAGPL 651_ FSENT 656_ LQFYN 661_ ERVVI 666_ MNSIL 671_ ERMCA 676_ DVLQQ 681_ TATQI 686_ KFPST 691_ GVDTM 696_ PYWNL 701_ LPPKR 706_ PIKEV 711_ LTDIF 716_ AKVLE 721_ KGWVD 726_ SRSIH 731_ IFDTL 736_ LHMGG 741_ VYWFC 746_ NNLIK 751_ ELLKE 756_ TRKEH 761_ TLRAV 766_ ELLYS 771_ IFCLD 776_ MQQVT 781_ LVLLG 786_ HILPG 791_ LLTDS 796_ SKWHS 801_ LMDPP 806_ GTALA 811_ KLAVW 816_ CALSS 821_ YSSHK 826_ GQAST 831_ RQKKR 836_ HREDI 841_ EDYIS 846_ LFPLD 851_ DVQPS 856_ KLMRL 861_ LSSNE 866_ DDANI 871_ LSSPT 876_ DRSMS 881_ SSLSA 886_ SQLHT 891_ VNMRD 896_ PLNRV 901_ LANLF 906_ LLISS 911_ ILGSR 916_ TAGPH 921_ TQFVQ 926_ WFMEE 931_ CVDCL 936_ EQGGR 941_ GSVLQ 946_ FMPFT 951_ TVSEL 956_ VKVSA 961_ MSSPK 966_ VVLAI 971_ TDLSL 976_ PLGRQ 981_VAAKA
1: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors