Katanin p60 ATPase-containing subunit A1 (Katanin p60 subunit A1) (EC 5.6.1.1) (p60 katanin)
1_MSLLM 6_ ISENV 11_ KLARE 16_ YALLG 21_ NYDSA 26_ MVYYQ 31_ GVLDQ 36_ MNKYL 41_ YSVKD 46_ TYLQQ 51_ KWQQV 56_ WQEIN 61_ VEAKH 66_ VKDIM 71_ KTLES 76_ FKLDS 81_ TPLKA 86_ AQHDL 91_ PASEG 96_ EVWSM 101_ PVPVE 106_ RRPSP 111_ GPRKR 116_ QSSQY 121_ SDPKS 126_ HGNRP 131_ STTVR 136_ VHRSS 141_ AQNVH 146_ NDRGK 151_ AVRCR 156_ EKKEQ 161_ NKGRE 166_ EKNKS 171_ PAAVT 176_ EPETN 181_ KFDST 186_ GYDKD 191_ LVEAL 196_ ERDII 201_ SQNPN 206_ VRWDD 211_ IADLV 216_ EAKKL 221_ LKEAV 226_ VLPMW 231_ MPEFF 236_ KGIRR 241_ PWKGV 246_ LMVGP 251_ PGTGK 256_ TLLAK 261_ AVATE 266_ CKTTF 271_ FNVSS 276_ STLTS 281_ KYRGE 286_ SEKLV 291_ RLLFE 296_ MARFY 301_ SPATI 306_ FIDEI 311_ DSICS 316_ RRGTS 321_ EEHEA 326_ SRRVK 331_ AELLV 336_ QMDGV 341_ GGTSE 346_ NDDPS 351_ KMVMV 356_ LAATN 361_ FPWDI 366_ DEALR 371_ RRLEK 376_ RIYIP 381_ LPSAK 386_ GREEL 391_ LRISL 396_ RELEL 401_ ADDVD 406_ LASIA 411_ ENMEG 416_ YSGAD 421_ ITNVC 426_ RDASL 431_ MAMRR 436_ RIEGL 441_ TPEEI 446_ RNLSK 451_ EEMHM 456_ PTTME 461_ DFEMA 466_ LKKVS 471_ KSVSA 476_ ADIER 481_ YEKWI 486_FEFGS
1: Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth