Retinol dehydrogenase 16 (EC 1.1.1.105) (EC 1.1.1.209) (EC 1.1.1.315) (EC 1.1.1.53) (Human epidermal retinol dehydrogenase) (hRDH-E) (Microsomal NAD(+)-dependent retinol dehydrogenase 4) (RoDH-4) (Short chain dehydrogenase/reductase family 9C member 8) (Sterol/retinol dehydrogenase)
1_MWLYL 6_ AVFVG 11_ LYYLL 16_ HWYRE 21_ RQVLS 26_ HLRDK 31_ YVFIT 36_ GCDSG 41_ FGKLL 46_ ARQLD 51_ ARGLR 56_ VLAAC 61_ LTEKG 66_ AEQLR 71_ GQTSD 76_ RLETV 81_ TLDVT 86_ KTESV 91_ AAAAQ 96_ WVKEC 101_ VRDKG 106_ LWGLV 111_ NNAGI 116_ SLPTA 121_ PNELL 126_ TKQDF 131_ VTILD 136_ VNLLG 141_ VIDVT 146_ LSLLP 151_ LVRRA 156_ RGRVV 161_ NVSSV 166_ MGRVS 171_ LFGGG 176_ YCISK 181_ YGVEA 186_ FSDSL 191_ RRELS 196_ YFGVK 201_ VAMIE 206_ PGYFK 211_ TAVTS 216_ KERFL 221_ KSFLE 226_ IWDRS 231_ SPEVK 236_ EAYGE 241_ KFVAD 246_ YKKSA 251_ EQMEQ 256_ KCTQD 261_ LSLVT 266_ NCMEH 271_ ALIAC 276_ HPRTR 281_ YSAGW 286_ DAKLL 291_ YLPMS 296_ YMPTF 301_ LVDAI 306_ MYWVS 311_PSPAK
1: Oxidoreductase with a preference for NAD. Oxidizes all-trans-retinol, 9-cis-retinol, 11-cis-retinol and 13-cis-retinol to the corresponding aldehydes (PubMed:10329026, PubMed:12534290, PubMed:9677409). Has higher activity towards CRBP-bound retinol than with free retinol (PubMed:12534290). Also oxidizes 3-alpha-hydroxysteroids. Oxidizes androstanediol and androsterone to dihydrotestosterone and androstanedione. Can also catalyze the reverse reaction (PubMed:10329026, PubMed:29541409, PubMed:9677409)