Serine/threonine-protein kinase/endoribonuclease IRE1 (Endoplasmic reticulum-to-nucleus signaling 1) (Inositol-requiring protein 1) (hIRE1p) (Ire1-alpha) (IRE1a) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)]
1_MPARR 6_ LLLLL 11_ TLLLP 16_ GLGIF 21_ GSTST 26_ VTLPE 31_ TLLFV 36_ STLDG 41_ SLHAV 46_ SKRTG 51_ SIKWT 56_ LKEDP 61_ VLQVP 66_ THVEE 71_ PAFLP 76_ DPNDG 81_ SLYTL 86_ GSKNN 91_ EGLTK 96_ LPFTI 101_ PELVQ 106_ ASPCR 111_ SSDGI 116_ LYMGK 121_ KQDIW 126_ YVIDL 131_ LTGEK 136_ QQTLS 141_ SAFAD 146_ SLCPS 151_ TSLLY 156_ LGRTE 161_ YTITM 166_ YDTKT 171_ RELRW 176_ NATYF 181_ DYAAS 186_ LPEDD 191_ VDYKM 196_ SHFVS 201_ NGDGL 206_ VVTVD 211_ SESGD 216_ VLWIQ 221_ NYASP 226_ VVAFY 231_ VWQRE 236_ GLRKV 241_ MHINV 246_ AVETL 251_ RYLTF 256_ MSGEV 261_ GRITK 266_ WKYPF 271_ PKETE 276_ AKSKL 281_ TPTLY 286_ VGKYS 291_ TSLYA 296_ SPSMV 301_ HEGVA 306_ VVPRG 311_ STLPL 316_ LEGPQ 321_ TDGVT 326_ IGDKG 331_ ECVIT 336_ PSTDV 341_ KFDPG 346_ LKSKN 351_ KLNYL 356_ RNYWL 361_ LIGHH 366_ ETPLS 371_ ASTKM 376_ LERFP 381_ NNLPK 386_ HRENV 391_ IPADS 396_ EKKSF 401_ EEVIN 406_ LVDQT 411_ SENAP 416_ TTVSR 421_ DVEEK 426_ PAHAP 431_ ARPEA 436_ PVDSM 441_ LKDMA 446_ TIILS 451_ TFLLI 456_ GWVAF 461_ IITYP 466_ LSMHQ 471_ QQQLQ 476_ HQQFQ 481_ KELEK 486_ IQLLQ 491_ QQQQQ 496_ LPFHP 501_ PGDTA 506_ QDGEL 511_ LDTSG 516_ PYSES 521_ SGTSS 526_ PSTSP 531_ RASNH 536_ SLCSG 541_ SSASK 546_ AGSSP 551_ SLEQD 556_ DGDEE 561_ TSVVI 566_ VGKIS 571_ FCPKD 576_ VLGHG 581_ AEGTI 586_ VYRGM 591_ FDNRD 596_ VAVKR 601_ ILPEC 606_ FSFAD 611_ REVQL 616_ LRESD 621_ EHPNV 626_ IRYFC 631_ TEKDR 636_ QFQYI 641_ AIELC 646_ AATLQ 651_ EYVEQ 656_ KDFAH 661_ LGLEP 666_ ITLLQ 671_ QTTSG 676_ LAHLH 681_ SLNIV 686_ HRDLK 691_ PHNIL 696_ ISMPN 701_ AHGKI 706_ KAMIS 711_ DFGLC 716_ KKLAV 721_ GRHSF 726_ SRRSG 731_ VPGTE 736_ GWIAP 741_ EMLSE 746_ DCKEN 751_ PTYTV 756_ DIFSA 761_ GCVFY 766_ YVISE 771_ GSHPF 776_ GKSLQ 781_ RQANI 786_ LLGAC 791_ SLDCL 796_ HPEKH 801_ EDVIA 806_ RELIE 811_ KMIAM 816_ DPQKR 821_ PSAKH 826_ VLKHP 831_ FFWSL 836_ EKQLQ 841_ FFQDV 846_ SDRIE 851_ KESLD 856_ GPIVK 861_ QLERG 866_ GRAVV 871_ KMDWR 876_ ENITV 881_ PLQTD 886_ LRKFR 891_ TYKGG 896_ SVRDL 901_ LRAMR 906_ NKKHH 911_ YRELP 916_ AEVRE 921_ TLGSL 926_ PDDFV 931_ CYFTS 936_ RFPHL 941_ LAHTY 946_ RAMEL 951_ CSHER 956_ LFQPY 961_ YFHEP 966_ PEPQP 971_PVTPD
1: Serine/threonine-protein kinase and endoribonuclease that acts as a key sensor for the endoplasmic reticulum unfolded protein response (UPR) (PubMed:11175748, PubMed:11779464, PubMed:12637535, PubMed:19328063, PubMed:21317875, PubMed:28128204, PubMed:30118681, PubMed:36739529, PubMed:9637683). In unstressed cells, the endoplasmic reticulum luminal domain is maintained in its inactive monomeric state by binding to the endoplasmic reticulum chaperone HSPA5/BiP (PubMed:21317875). Accumulation of misfolded proteins in the endoplasmic reticulum causes release of HSPA5/BiP, allowing the luminal domain to homodimerize, promoting autophosphorylation of the kinase domain and subsequent activation of the endoribonuclease activity (PubMed:21317875). The endoribonuclease activity is specific for XBP1 mRNA and excises 26 nucleotides from XBP1 mRNA (PubMed:11779464, PubMed:21317875, PubMed:24508390). The resulting spliced transcript of XBP1 encodes a transcriptional activator protein that up-regulates expression of UPR target genes (PubMed:11779464, PubMed:21317875, PubMed:24508390). Acts as an upstream signal for ER stress-induced GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane by modulating the expression and localization of SEC16A (PubMed:21884936, PubMed:28067262)