Transcription factor E2F6 (E2F-6)
1_MSQQR 6_ PARKL 11_ PSLLL 16_ DPTEE 21_ TVRRR 26_ CRDPI 31_ NVEGL 36_ LPSKI 41_ RINLE 46_ DNVQY 51_ VSMRK 56_ ALKVK 61_ RPRFD 66_ VSLVY 71_ LTRKF 76_ MDLVR 81_ SAPGG 86_ ILDLN 91_ KVATK 96_ LGVRK 101_ RRVYD 106_ ITNVL 111_ DGIDL 116_ VEKKS 121_ KNHIR 126_ WIGSD 131_ LSNFG 136_ AVPQQ 141_ KKLQE 146_ ELSDL 151_ SAMED 156_ ALDEL 161_ IKDCA 166_ QQLFE 171_ LTDDK 176_ ENERL 181_ AYVTY 186_ QDIHS 191_ IQAFH 196_ EQIVI 201_ AVKAP 206_ AETRL 211_ DVPAP 216_ REDSI 221_ TVHIR 226_ STNGP 231_ IDVYL 236_ CEVEQ 241_ GQTSN 246_ KRSEG 251_ VGTSS 256_ SESTH 261_ PEGPE 266_ EEENP 271_ QQSEE 276_LLEVS
1: Inhibitor of E2F-dependent transcription (PubMed:9501179, PubMed:9689056, PubMed:9704927). Binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' (PubMed:9501179). Has a preference for the 5'-TTTCCCGC-3' E2F recognition site (PubMed:9501179). E2F6 lacks the transcriptional activation and pocket protein binding domains (PubMed:9501179, PubMed:9704927). Appears to regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression (PubMed:9501179, PubMed:9689056). Represses expression of some meiosis-specific genes, including SLC25A31/ANT4 (By similarity). May silence expression via the recruitment of a chromatin remodeling complex containing histone H3-K9 methyltransferase activity. Overexpression delays the exit of cells from the S-phase (PubMed:9501179)