Nuclear receptor subfamily 1 group I member 2 (Orphan nuclear receptor PAR1) (Orphan nuclear receptor PXR) (Pregnane X receptor) (Steroid and xenobiotic receptor) (SXR)
1_MEVRP 6_ KESWN 11_ HADFV 16_ HCEDT 21_ ESVPG 26_ KPSVN 31_ ADEEV 36_ GGPQI 41_ CRVCG 46_ DKATG 51_ YHFNV 56_ MTCEG 61_ CKGFF 66_ RRAMK 71_ RNARL 76_ RCPFR 81_ KGACE 86_ ITRKT 91_ RRQCQ 96_ ACRLR 101_ KCLES 106_ GMKKE 111_ MIMSD 116_ EAVEE 121_ RRALI 126_ KRKKS 131_ ERTGT 136_ QPLGV 141_ QGLTE 146_ EQRMM 151_ IRELM 156_ DAQMK 161_ TFDTT 166_ FSHFK 171_ NFRLP 176_ GVLSS 181_ GCELP 186_ ESLQA 191_ PSREE 196_ AAKWS 201_ QVRKD 206_ LCSLK 211_ VSLQL 216_ RGEDG 221_ SVWNY 226_ KPPAD 231_ SGGKE 236_ IFSLL 241_ PHMAD 246_ MSTYM 251_ FKGII 256_ SFAKV 261_ ISYFR 266_ DLPIE 271_ DQISL 276_ LKGAA 281_ FELCQ 286_ LRFNT 291_ VFNAE 296_ TGTWE 301_ CGRLS 306_ YCLED 311_ TAGGF 316_ QQLLL 321_ EPMLK 326_ FHYML 331_ KKLQL 336_ HEEEY 341_ VLMQA 346_ ISLFS 351_ PDRPG 356_ VLQHR 361_ VVDQL 366_ QEQFA 371_ ITLKS 376_ YIECN 381_ RPQPA 386_ HRFLF 391_ LKIMA 396_ MLTEL 401_ RSINA 406_ QHTQR 411_ LLRIQ 416_ DIHPF 421_ ATPLM 426_QELFG
1: Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes