Leucine-rich repeat-containing G-protein coupled receptor 5 (G-protein coupled receptor 49) (G-protein coupled receptor 67) (G-protein coupled receptor HG38)
1_MDTSR 6_ LGVLL 11_ SLPVL 16_ LQLAT 21_ GGSSP 26_ RSGVL 31_ LRGCP 36_ THCHC 41_ EPDGR 46_ MLLRV 51_ DCSDL 56_ GLSEL 61_ PSNLS 66_ VFTSY 71_ LDLSM 76_ NNISQ 81_ LLPNP 86_ LPSLR 91_ FLEEL 96_ RLAGN 101_ ALTYI 106_ PKGAF 111_ TGLYS 116_ LKVLM 121_ LQNNQ 126_ LRHVP 131_ TEALQ 136_ NLRSL 141_ QSLRL 146_ DANHI 151_ SYVPP 156_ SCFSG 161_ LHSLR 166_ HLWLD 171_ DNALT 176_ EIPVQ 181_ AFRSL 186_ SALQA 191_ MTLAL 196_ NKIHH 201_ IPDYA 206_ FGNLS 211_ SLVVL 216_ HLHNN 221_ RIHSL 226_ GKKCF 231_ DGLHS 236_ LETLD 241_ LNYNN 246_ LDEFP 251_ TAIRT 256_ LSNLK 261_ ELGFH 266_ SNNIR 271_ SIPEK 276_ AFVGN 281_ PSLIT 286_ IHFYD 291_ NPIQF 296_ VGRSA 301_ FQHLP 306_ ELRTL 311_ TLNGA 316_ SQITE 321_ FPDLT 326_ GTANL 331_ ESLTL 336_ TGAQI 341_ SSLPQ 346_ TVCNQ 351_ LPNLQ 356_ VLDLS 361_ YNLLE 366_ DLPSF 371_ SVCQK 376_ LQKID 381_ LRHNE 386_ IYEIK 391_ VDTFQ 396_ QLLSL 401_ RSLNL 406_ AWNKI 411_ AIIHP 416_ NAFST 421_ LPSLI 426_ KLDLS 431_ SNLLS 436_ SFPIT 441_ GLHGL 446_ THLKL 451_ TGNHA 456_ LQSLI 461_ SSENF 466_ PELKV 471_ IEMPY 476_ AYQCC 481_ AFGVC 486_ ENAYK 491_ ISNQW 496_ NKGDN 501_ SSMDD 506_ LHKKD 511_ AGMFQ 516_ AQDER 521_ DLEDF 526_ LLDFE 531_ EDLKA 536_ LHSVQ 541_ CSPSP 546_ GPFKP 551_ CEHLL 556_ DGWLI 561_ RIGVW 566_ TIAVL 571_ ALTCN 576_ ALVTS 581_ TVFRS 586_ PLYIS 591_ PIKLL 596_ IGVIA 601_ AVNML 606_ TGVSS 611_ AVLAG 616_ VDAFT 621_ FGSFA 626_ RHGAW 631_ WENGV 636_ GCHVI 641_ GFLSI 646_ FASES 651_ SVFLL 656_ TLAAL 661_ ERGFS 666_ VKYSA 671_ KFETK 676_ APFSS 681_ LKVII 686_ LLCAL 691_ LALTM 696_ AAVPL 701_ LGGSK 706_ YGASP 711_ LCLPL 716_ PFGEP 721_ STMGY 726_ MVALI 731_ LLNSL 736_ CFLMM 741_ TIAYT 746_ KLYCN 751_ LDKGD 756_ LENIW 761_ DCSMV 766_ KHIAL 771_ LLFTN 776_ CILNC 781_ PVAFL 786_ SFSSL 791_ INLTF 796_ ISPEV 801_ IKFIL 806_ LVVVP 811_ LPACL 816_ NPLLY 821_ ILFNP 826_ HFKED 831_ LVSLR 836_ KQTYV 841_ WTRSK 846_ HPSLM 851_ SINSD 856_ DVEKQ 861_ SCDST 866_ QALVT 871_ FTSSS 876_ ITYDL 881_ PPSSV 886_ PSPAY 891_ PVTES 896_ CHLSS 901_VAFVP
1: Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development