PC4 and SFRS1-interacting protein (CLL-associated antigen KW-7) (Dense fine speckles 70 kDa protein) (DFS 70) (Lens epithelium-derived growth factor) (Transcriptional coactivator p75/p52)
1_MTRDF 6_ KPGDL 11_ IFAKM 16_ KGYPH 21_ WPARV 26_ DEVPD 31_ GAVKP 36_ PTNKL 41_ PIFFF 46_ GTHET 51_ AFLGP 56_ KDIFP 61_ YSENK 66_ EKYGK 71_ PNKRK 76_ GFNEG 81_ LWEID 86_ NNPKV 91_ KFSSQ 96_ QAATK 101_ QSNAS 106_ SDVEV 111_ EEKET 116_ SVSKE 121_ DTDHE 126_ EKASN 131_ EDVTK 136_ AVDIT 141_ TPKAA 146_ RRGRK 151_ RKAEK 156_ QVETE 161_ EAGVV 166_ TTATA 171_ SVNLK 176_ VSPKR 181_ GRPAA 186_ TEVKI 191_ PKPRG 196_ RPKMV 201_ KQPCP 206_ SESDI 211_ ITEED 216_ KSKKK 221_ GQEEK 226_ QPKKQ 231_ PKKDE 236_ EGQKE 241_ EDKPR 246_ KEPDK 251_ KEGKK 256_ EVESK 261_ RKNLA 266_ KTGVT 271_ STSDS 276_ EEEGD 281_ DQEGE 286_ KKRKG 291_ GRNFQ 296_ TAHRR 301_ NMLKG 306_ QHEKE 311_ AADRK 316_ RKQEE 321_ QMETE 326_ QQNKD 331_ EGKKP 336_ EVKKV 341_ EKKRE 346_ TSMDS 351_ RLQRI 356_ HAEIK 361_ NSLKI 366_ DNLDV 371_ NRCIE 376_ ALDEL 381_ ASLQV 386_ TMQQA 391_ QKHTE 396_ MITTL 401_ KKIRR 406_ FKVSQ 411_ VIMEK 416_ STMLY 421_ NKFKN 426_ MFLVG 431_ EGDSV 436_ ITQVL 441_ NKSLA 446_ EQRQH 451_ EEANK 456_ TKDQG 461_ KKGPN 466_ KKLEK 471_ EQTGS 476_ KTLNG 481_ GSDAQ 486_ DGNQP 491_ QHNGE 496_ SNEDS 501_ KDNHE 506_ ASTKK 511_ KPSSE 516_ ERETE 521_ISLKD
1: Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration