Erlin-1 (Endoplasmic reticulum lipid raft-associated protein 1) (Protein KE04) (Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 1) (SPFH domain-containing protein 1)
1_MNMTQ 6_ ARVLV 11_ AAVVG 16_ LVAVL 21_ LYASI 26_ HKIEE 31_ GHLAV 36_ YYRGG 41_ ALLTS 46_ PSGPG 51_ YHIML 56_ PFITT 61_ FRSVQ 66_ TTLQT 71_ DEVKN 76_ VPCGT 81_ SGGVM 86_ IYIDR 91_ IEVVN 96_ MLAPY 101_ AVFDI 106_ VRNYT 111_ ADYDK 116_ TLIFN 121_ KIHHE 126_ LNQFC 131_ SAHTL 136_ QEVYI 141_ ELFDQ 146_ IDENL 151_ KQALQ 156_ KDLNL 161_ MAPGL 166_ TIQAV 171_ RVTKP 176_ KIPEA 181_ IRRNF 186_ ELMEA 191_ EKTKL 196_ LIAAQ 201_ KQKVV 206_ EKEAE 211_ TERKK 216_ AVIEA 221_ EKIAQ 226_ VAKIR 231_ FQQKV 236_ MEKET 241_ EKRIS 246_ EIEDA 251_ AFLAR 256_ EKAKA 261_ DAEYY 266_ AAHKY 271_ ATSNK 276_ HKLTP 281_ EYLEL 286_ KKYQA 291_ IASNS 296_ KIYFG 301_ SNIPN 306_ MFVDS 311_ SCALK 316_ YSDIR 321_ TGRES 326_ SLPSK 331_ EALEP 336_ SGENV 341_IQNKE
1: Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway (PubMed:37683630). Binds cholesterol and may promote ER retention of the SCAP-SREBF complex (PubMed:24217618)
2: (Microbial infection) Required early in hepatitis C virus (HCV) infection to initiate RNA replication, and later in the infection to support infectious virus production