Transcriptional adapter 2-alpha (Transcriptional adapter 2-like) (ADA2-like protein)
1_MDRLG 6_ PFSND 11_ PSDKP 16_ PCRGC 21_ SSYLM 26_ EPYIK 31_ CAECG 36_ PPPFF 41_ LCLQC 46_ FTRGF 51_ EYKKH 56_ QSDHT 61_ YEIMT 66_ SDFPV 71_ LDPSW 76_ TAQEE 81_ MALLE 86_ AVMDC 91_ GFGNW 96_ QDVAN 101_ QMCTK 106_ TKEEC 111_ EKHYM 116_ KHFIN 121_ NPLFA 126_ STLLN 131_ LKQAE 136_ EAKTA 141_ DTAIP 146_ FHSTD 151_ DPPRP 156_ TFDSL 161_ LSRDM 166_ AGYMP 171_ ARADF 176_ IEEFD 181_ NYAEW 186_ DLRDI 191_ DFVED 196_ DSDIL 201_ HALKM 206_ AVVDI 211_ YHSRL 216_ KERQR 221_ RKKII 226_ RDHGL 231_ INLRK 236_ FQLME 241_ RRYPK 246_ EVQDL 251_ YETMR 256_ RFARI 261_ VGPVE 266_ HDKFI 271_ ESHAL 276_ EFELR 281_ REIKR 286_ LQEYR 291_ TAGIT 296_ NFCSA 301_ RTYDH 306_ LKKTR 311_ EEERL 316_ KRTML 321_ SEVLQ 326_ YIQDS 331_ SACQQ 336_ WLRRQ 341_ ADIDS 346_ GLSPS 351_ IPMAS 356_ NSGRR 361_ SAPPL 366_ NLTGL 371_ PGTEK 376_ LNEKE 381_ KELCQ 386_ MVRLV 391_ PGAYL 396_ EYKSA 401_ LLNEC 406_ NKQGG 411_ LRLAQ 416_ ARALI 421_ KIDVN 426_ KTRKI 431_ YDFLI 436_REGYI
1: Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site (By similarity). Binds double-stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling. May promote TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity (PubMed:22644376). May also promote XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage (PubMed:22644376)