Serine/arginine-rich splicing factor 10 (40 kDa SR-repressor protein) (SRrp40) (FUS-interacting serine-arginine-rich protein 1) (Splicing factor SRp38) (Splicing factor, arginine/serine-rich 13A) (TLS-associated protein with Ser-Arg repeats) (TASR) (TLS-associated protein with SR repeats) (TLS-associated serine-arginine protein) (TLS-associated SR protein)
1_MSRYL 6_ RPPNT 11_ SLFVR 16_ NVADD 21_ TRSED 26_ LRREF 31_ GRYGP 36_ IVDVY 41_ VPLDF 46_ YTRRP 51_ RGFAY 56_ VQFED 61_ VRDAE 66_ DALHN 71_ LDRKW 76_ ICGRQ 81_ IEIQF 86_ AQGDR 91_ KTPNQ 96_ MKAKE 101_ GRNVY 106_ SSSRY 111_ DDYDR 116_ YRRSR 121_ SRSYE 126_ RRRSR 131_ SRSFD 136_ YNYRR 141_ SYSPR 146_ NSRPT 151_ GRPRR 156_ SRSHS 161_ DNDRF 166_ KHRNR 171_ SFSRS 176_ KSNSR 181_ SRSKS 186_ QPKKE 191_ MKAKS 196_ RSRSA 201_ SHTKT 206_ RGTSK 211_ TDSKT 216_ HYKSG 221_ SRYEK 226_ ESRKK 231_ EPPRS 236_ KSQSR 241_ SQSRS 246_ RSKSR 251_ SRSWT 256_SPKSS
1: Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing (PubMed:11684676, PubMed:12419250, PubMed:14765198). Seems to interfere with the U1 snRNP 5'-splice recognition of SNRNP70 (PubMed:14765198). Required for splicing repression in M-phase cells and after heat shock (PubMed:14765198). Also acts as a splicing factor that specifically promotes exon skipping during alternative splicing (PubMed:26876937). Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937). May be involved in regulation of alternative splicing in neurons, with isoform 1 acting as a positive and isoform 3 as a negative regulator (PubMed:12419250)