Geminin
1_MNPSM 6_ KQKQE 11_ EIKEN 16_ IKNSS 21_ VPRRT 26_ LKMIQ 31_ PSASG 36_ SLVGR 41_ ENELS 46_ AGLSK 51_ RKHRN 56_ DHLTS 61_ TTSSP 66_ GVIVP 71_ ESSEN 76_ KNLGG 81_ VTQES 86_ FDLMI 91_ KENPS 96_ SQYWK 101_ EVAEK 106_ RRKAL 111_ YEALK 116_ ENEKL 121_ HKEIE 126_ QKDNE 131_ IARLK 136_ KENKE 141_ LAEVA 146_ EHVQY 151_ MAELI 156_ ERLNG 161_ EPLDN 166_ FESLD 171_ NQEFD 176_ SEEET 181_ VEDSL 186_ VEDSE 191_ IGTCA 196_ EGTVS 201_SSTDA
1: Inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex (pre-RC) (PubMed:14993212, PubMed:20129055, PubMed:24064211, PubMed:9635433). It is degraded during the mitotic phase of the cell cycle (PubMed:14993212, PubMed:24064211, PubMed:9635433). Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle (PubMed:14993212, PubMed:24064211, PubMed:9635433). Inhibits histone acetyltransferase activity of KAT7/HBO1 in a CDT1-dependent manner, inhibiting histone H4 acetylation and DNA replication licensing (PubMed:20129055). Inhibits the transcriptional activity of a subset of Hox proteins, enrolling them in cell proliferative control (PubMed:22615398)