Ceroid-lipofuscinosis neuronal protein 5 (Protein CLN5) [Cleaved into: Ceroid-lipofuscinosis neuronal protein 5, secreted form]
1_MAQEV 6_ DTAQG 11_ AEMRR 16_ GAGAA 21_ RGRAS 26_ WCWAL 31_ ALLWL 36_ AVVPG 41_ WSRVS 46_ GIPSR 51_ RHWPV 56_ PYKRF 61_ DFRPK 66_ PDPYC 71_ QAKYT 76_ FCPTG 81_ SPIPV 86_ MEGDD 91_ DIEVF 96_ RLQAP 101_ VWEFK 106_ YGDLL 111_ GHLKI 116_ MHDAI 121_ GFRST 126_ LTGKN 131_ YTMEW 136_ YELFQ 141_ LGNCT 146_ FPHLR 151_ PEMDA 156_ PFWCN 161_ QGAAC 166_ FFEGI 171_ DDVHW 176_ KENGT 181_ LVQVA 186_ TISGN 191_ MFNQM 196_ AKWVK 201_ QDNET 206_ GIYYE 211_ TWNVK 216_ ASPEK 221_ GAETW 226_ FDSYD 231_ CSKFV 236_ LRTFN 241_ KLAEF 246_ GAEFK 251_ NIETN 256_ YTRIF 261_ LYSGE 266_ PTYLG 271_ NETSV 276_ FGPTG 281_ NKTLG 286_ LAIKR 291_ FYYPF 296_ KPHLP 301_ TKEFL 306_ LSLLQ 311_ IFDAV 316_ IVHKQ 321_ FYLFY 326_ NFEYW 331_ FLPMK 336_ FPFIK 341_ ITYEE 346_ IPLPI 351_RNKTL
1: Catalyzes the synthesis of bis(monoacylglycero)phosphate (BMP) via transacylation of 2 molecules of lysophosphatidylglycerol (LPG) (PubMed:37708259). BMP also known as lysobisphosphatidic acid plays a key role in the formation of intraluminal vesicles and in maintaining intracellular cholesterol homeostasis (PubMed:37708259). Can use only LPG as the exclusive lysophospholipid acyl donor for base exchange and displays BMP synthase activity towards various LPGs (LPG 14:0, LPG 16:0, LPG 18:0, LPG 18:1) with a higher preference for longer chain lengths (PubMed:37708259). Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane (PubMed:22431521). Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane (PubMed:22431521)
2: Exhibits palmitoyl protein thioesterase (S-depalmitoylation) activity in vitro and most likely plays a role in protein S-depalmitoylation