KH domain-containing, RNA-binding, signal transduction-associated protein 3 (RNA-binding protein T-Star) (Sam68-like mammalian protein 2) (SLM-2) (Sam68-like phosphotyrosine protein)
1_MEEKY 6_ LPELM 11_ AEKDS 16_ LDPSF 21_ THALR 26_ LVNQE 31_ IEKFQ 36_ KGEGK 41_ DEEKY 46_ IDVVI 51_ NKNMK 56_ LGQKV 61_ LIPVK 66_ QFPKF 71_ NFVGK 76_ LLGPR 81_ GNSLK 86_ RLQEE 91_ TLTKM 96_ SILGK 101_ GSMRD 106_ KAKEE 111_ ELRKS 116_ GEAKY 121_ FHLND 126_ DLHVL 131_ IEVFA 136_ PPAEA 141_ YARMG 146_ HALEE 151_ IKKFL 156_ IPDYN 161_ DEIRQ 166_ AQLQE 171_ LTYLN 176_ GGSEN 181_ ADVPV 186_ VRGKP 191_ TLRTR 196_ GVPAP 201_ AITRG 206_ RGGVT 211_ ARPVG 216_ VVVPR 221_ GTPTP 226_ RGVLS 231_ TRGPV 236_ SRGRG 241_ LLTPR 246_ ARGVP 251_ PTGYR 256_ PPPPP 261_ PTQET 266_ YGEYD 271_ YDDGY 276_ GTAYD 281_ EQSYD 286_ SYDNS 291_ YSTPA 296_ QSGAD 301_ YYDYG 306_ HGLSE 311_ ETYDS 316_ YGQEE 321_ WTNSR 326_ HKAPS 331_ ARTAK 336_ GVYRD 341_QPYGR
1: RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds preferentially to the 5'-[AU]UAAA-3' motif in vitro. Binds optimally to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). RNA-binding abilities are down-regulated by tyrosine kinase PTK6 (PubMed:10564820, PubMed:19561594, PubMed:26758068). Involved in splice site selection of vascular endothelial growth factor (PubMed:15901763). In vitro regulates CD44 alternative splicing by direct binding to purine-rich exonic enhancer (By similarity). Can regulate alternative splicing of neurexins NRXN1-3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners such as neuroligins and LRRTM family members (PubMed:26758068). Targeted, cell-type specific splicing regulation of NRXN1 at AS4 is involved in neuronal glutamatergic synapse function and plasticity (By similarity). May regulate expression of KHDRBS2/SLIM-1 in defined brain neuron populations by modifying its alternative splicing (By similarity). Can bind FABP9 mRNA (By similarity). May play a role as a negative regulator of cell growth. Inhibits cell proliferation
2: (Microbial infection) Involved in post-transcriptional regulation of HIV-1 gene expression