Polycomb protein EED (hEED) (Embryonic ectoderm development protein) (WD protein associating with integrin cytoplasmic tails 1) (WAIT-1)
1_MSERE 6_ VSTAP 11_ AGTDM 16_ PAAKK 21_ QKLSS 26_ DENSN 31_ PDLSG 36_ DENDD 41_ AVSIE 46_ SGTNT 51_ ERPDT 56_ PTNTP 61_ NAPGR 66_ KSWGK 71_ GKWKS 76_ KKCKY 81_ SFKCV 86_ NSLKE 91_ DHNQP 96_ LFGVQ 101_ FNWHS 106_ KEGDP 111_ LVFAT 116_ VGSNR 121_ VTLYE 126_ CHSQG 131_ EIRLL 136_ QSYVD 141_ ADADE 146_ NFYTC 151_ AWTYD 156_ SNTSH 161_ PLLAV 166_ AGSRG 171_ IIRII 176_ NPITM 181_ QCIKH 186_ YVGHG 191_ NAINE 196_ LKFHP 201_ RDPNL 206_ LLSVS 211_ KDHAL 216_ RLWNI 221_ QTDTL 226_ VAIFG 231_ GVEGH 236_ RDEVL 241_ SADYD 246_ LLGEK 251_ IMSCG 256_ MDHSL 261_ KLWRI 266_ NSKRM 271_ MNAIK 276_ ESYDY 281_ NPNKT 286_ NRPFI 291_ SQKIH 296_ FPDFS 301_ TRDIH 306_ RNYVD 311_ CVRWL 316_ GDLIL 321_ SKSCE 326_ NAIVC 331_ WKPGK 336_ MEDDI 341_ DKIKP 346_ SESNV 351_ TILGR 356_ FDYSQ 361_ CDIWY 366_ MRFSM 371_ DFWQK 376_ MLALG 381_ NQVGK 386_ LYVWD 391_ LEVED 396_ PHKAK 401_ CTTLT 406_ HHKCG 411_ AAIRQ 416_ TSFSR 421_ DSSIL 426_ IAVCD 431_ DASIW 436_RWDRL
1: Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A