Splicing factor 3B subunit 1 (Pre-mRNA-splicing factor SF3b 155 kDa subunit) (SF3b155) (Spliceosome-associated protein 155) (SAP 155)
1_MAKIA 6_ KTHED 11_ IEAQI 16_ REIQG 21_ KKAAL 26_ DEAQG 31_ VGLDS 36_ TGYYD 41_ QEIYG 46_ GSDSR 51_ FAGYV 56_ TSIAA 61_ TELED 66_ DDDDY 71_ SSSTS 76_ LLGQK 81_ KPGYH 86_ APVAL 91_ LNDIP 96_ QSTEQ 101_ YDPFA 106_ EHRPP 111_ KIADR 116_ EDEYK 121_ KHRRT 126_ MIISP 131_ ERLDP 136_ FADGG 141_ KTPDP 146_ KMNAR 151_ TYMDV 156_ MREQH 161_ LTKEE 166_ REIRQ 171_ QLAEK 176_ AKAGE 181_ LKVVN 186_ GAAAS 191_ QPPSK 196_ RKRRW 201_ DQTAD 206_ QTPGA 211_ TPKKL 216_ SSWDQ 221_ AETPG 226_ HTPSL 231_ RWDET 236_ PGRAK 241_ GSETP 246_ GATPG 251_ SKIWD 256_ PTPSH 261_ TPAGA 266_ ATPGR 271_ GDTPG 276_ HATPG 281_ HGGAT 286_ SSARK 291_ NRWDE 296_ TPKTE 301_ RDTPG 306_ HGSGW 311_ AETPR 316_ TDRGG 321_ DSIGE 326_ TPTPG 331_ ASKRK 336_ SRWDE 341_ TPASQ 346_ MGGST 351_ PVLTP 356_ GKTPI 361_ GTPAM 366_ NMATP 371_ TPGHI 376_ MSMTP 381_ EQLQA 386_ WRWER 391_ EIDER 396_ NRPLS 401_ DEELD 406_ AMFPE 411_ GYKVL 416_ PPPAG 421_ YVPIR 426_ TPARK 431_ LTATP 436_ TPLGG 441_ MTGFH 446_ MQTED 451_ RTMKS 456_ VNDQP 461_ SGNLP 466_ FLKPD 471_ DIQYF 476_ DKLLV 481_ DVDES 486_ TLSPE 491_ EQKER 496_ KIMKL 501_ LLKIK 506_ NGTPP 511_ MRKAA 516_ LRQIT 521_ DKARE 526_ FGAGP 531_ LFNQI 536_ LPLLM 541_ SPTLE 546_ DQERH 551_ LLVKV 556_ IDRIL 561_ YKLDD 566_ LVRPY 571_ VHKIL 576_ VVIEP 581_ LLIDE 586_ DYYAR 591_ VEGRE 596_ IISNL 601_ AKAAG 606_ LATMI 611_ STMRP 616_ DIDNM 621_ DEYVR 626_ NTTAR 631_ AFAVV 636_ ASALG 641_ IPSLL 646_ PFLKA 651_ VCKSK 656_ KSWQA 661_ RHTGI 666_ KIVQQ 671_ IAILM 676_ GCAIL 681_ PHLRS 686_ LVEII 691_ EHGLV 696_ DEQQK 701_ VRTIS 706_ ALAIA 711_ ALAEA 716_ ATPYG 721_ IESFD 726_ SVLKP 731_ LWKGI 736_ RQHRG 741_ KGLAA 746_ FLKAI 751_ GYLIP 756_ LMDAE 761_ YANYY 766_ TREVM 771_ LILIR 776_ EFQSP 781_ DEEMK 786_ KIVLK 791_ VVKQC 796_ CGTDG 801_ VEANY 806_ IKTEI 811_ LPPFF 816_ KHFWQ 821_ HRMAL 826_ DRRNY 831_ RQLVD 836_ TTVEL 841_ ANKVG 846_ AAEII 851_ SRIVD 856_ DLKDE 861_ AEQYR 866_ KMVME 871_ TIEKI 876_ MGNLG 881_ AADID 886_ HKLEE 891_ QLIDG 896_ ILYAF 901_ QEQTT 906_ EDSVM 911_ LNGFG 916_ TVVNA 921_ LGKRV 926_ KPYLP 931_ QICGT 936_ VLWRL 941_ NNKSA 946_ KVRQQ 951_ AADLI 956_ SRTAV 961_ VMKTC 966_ QEEKL 971_ MGHLG 976_ VVLYE 981_ YLGEE 986_ YPEVL 991_ GSILG 996_ ALKAI 1001_ VNVIG 1006_ MHKMT 1011_ PPIKD 1016_ LLPRL 1021_ TPILK 1026_ NRHEK 1031_ VQENC 1036_ IDLVG 1041_ RIADR 1046_ GAEYV 1051_ SAREW 1056_ MRICF 1061_ ELLEL 1066_ LKAHK 1071_ KAIRR 1076_ ATVNT 1081_ FGYIA 1086_ KAIGP 1091_ HDVLA 1096_ TLLNN 1101_ LKVQE 1106_ RQNRV 1111_ CTTVA 1116_ IAIVA 1121_ ETCSP 1126_ FTVLP 1131_ ALMNE 1136_ YRVPE 1141_ LNVQN 1146_ GVLKS 1151_ LSFLF 1156_ EYIGE 1161_ MGKDY 1166_ IYAVT 1171_ PLLED 1176_ ALMDR 1181_ DLVHR 1186_ QTASA 1191_ VVQHM 1196_ SLGVY 1201_ GFGCE 1206_ DSLNH 1211_ LLNYV 1216_ WPNVF 1221_ ETSPH 1226_ VIQAV 1231_ MGALE 1236_ GLRVA 1241_ IGPCR 1246_ MLQYC 1251_ LQGLF 1256_ HPARK 1261_ VRDVY 1266_ WKIYN 1271_ SIYIG 1276_ SQDAL 1281_ IAHYP 1286_ RIYND 1291_ DKNTY 1296_IRYEL
1: Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:27720643, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3B1 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). Together with other U2 snRNP complex components may also play a role in the selective processing of microRNAs (miRNAs) from the long primary miRNA transcript, pri-miR-17-92 (By similarity)