Interferon-inducible double-stranded RNA-dependent protein kinase activator A (PKR-associated protein X) (PKR-associating protein X) (Protein activator of the interferon-induced protein kinase) (Protein kinase, interferon-inducible double-stranded RNA-dependent activator)
1_MSQSR 6_ HRAEA 11_ PPLER 16_ EDSGT 21_ FSLGK 26_ MITAK 31_ PGKTP 36_ IQVLH 41_ EYGMK 46_ TKNIP 51_ VYECE 56_ RSDVQ 61_ IHVPT 66_ FTFRV 71_ TVGDI 76_ TCTGE 81_ GTSKK 86_ LAKHR 91_ AAEAA 96_ INILK 101_ ANASI 106_ CFAVP 111_ DPLMP 116_ DPSKQ 121_ PKNQL 126_ NPIGS 131_ LQELA 136_ IHHGW 141_ RLPEY 146_ TLSQE 151_ GGPAH 156_ KREYT 161_ TICRL 166_ ESFME 171_ TGKGA 176_ SKKQA 181_ KRNAA 186_ EKFLA 191_ KFSNI 196_ SPENH 201_ ISLTN 206_ VVGHS 211_ LGCTW 216_ HSLRN 221_ SPGEK 226_ INLLK 231_ RSLLS 236_ IPNTD 241_ YIQLL 246_ SEIAK 251_ EQGFN 256_ ITYLD 261_ IDELS 266_ ANGQY 271_ QCLAE 276_ LSTSP 281_ ITVCH 286_ GSGIS 291_ CGNAQ 296_ SDAAH 301_ NALQY 306_LKIIA
1: Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at 'Lys-386' at 'Ser-392' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner (By similarity)