Peptide chain release factor 1, mitochondrial (MRF-1) (MtRF-1)
1_MNRHL 6_ CVWLF 11_ RHPSL 16_ NGYLQ 21_ CHIQL 26_ HSHQF 31_ RQIHL 36_ DTRLQ 41_ VFRQN 46_ RNCIL 51_ HLLSK 56_ NWSRR 61_ YCHQD 66_ TKMLW 71_ KHKAL 76_ QKYME 81_ NLSKE 86_ YQTLE 91_ QCLQH 96_ IPVNE 101_ ENRRS 106_ LNRRH 111_ AELAP 116_ LAAIY 121_ QEIQE 126_ TEQAI 131_ EELES 136_ MCKSL 141_ NKQDE 146_ KQLQE 151_ LALEE 156_ RQTID 161_ QKINM 166_ LYNEL 171_ FQSLV 176_ PKEKY 181_ DKNDV 186_ ILEVT 191_ AGRTT 196_ GGDIC 201_ QQFTR 206_ EIFDM 211_ YQNYS 216_ CYKHW 221_ QFELL 226_ NYTPA 231_ DYGGL 236_ HHAAA 241_ RISGD 246_ GVYKH 251_ LKYEG 256_ GIHRV 261_ QRIPE 266_ VGLSS 271_ RMQRI 276_ HTGTM 281_ SVIVL 286_ PQPDE 291_ VDVKL 296_ DPKDL 301_ RIDTF 306_ RAKGA 311_ GGQHV 316_ NKTDS 321_ AVRLV 326_ HIPTG 331_ LVVEC 336_ QQERS 341_ QIKNK 346_ EIAFR 351_ VLRAR 356_ LYQQI 361_ IEKDK 366_ RQQQS 371_ ARKLQ 376_ VGTRA 381_ QSERI 386_ RTYNF 391_ TQDRV 396_ SDHRI 401_ AYEVR 406_ DIKEF 411_ LCGGK 416_ GLDQL 421_ IQRLL 426_ QSADE 431_ EAIAE 436_LLDEH
1: Mitochondrial peptide chain release factor that directs the termination of translation in response to the peptide chain non-canonical stop codons AGG and AGA (PubMed:36302763, PubMed:36596788, PubMed:37141370). Non-canonical termination codons AGG and AGA are found at the end of MT-CO1/COX1 and MT-ND6/ND6 open reading frames, respectively (PubMed:37141370). Recognizes non-canonical stop codons via a network of interactions between the codon, MTRF1 and the ribosomal RNA (rRNA): in contrast to other translation release factors, which identify the codon in the A-site via direct interactions of amino acid side chains with the bases, MTRF1 repositions the first 2 bases of the stop codon to use an intricate network of interactions that includes residues of the release factor, the rRNA of the small ribosomal subunit, as well as neighboring bases of the mRNA (PubMed:37141370)