DNA-directed RNA polymerase III subunit RPC9 (RNA polymerase III subunit C9) (Calcitonin gene-related peptide-receptor component protein) (CGRP-RCP) (CGRP-receptor component protein) (CGRPRCP) (HsC17)
1_MEVKD 6_ ANSAL 11_ LSNYE 16_ VFQLL 21_ TDLKE 26_ QRKES 31_ GKNKH 36_ SSGQQ 41_ NLNTI 46_ TYETL 51_ KYISK 56_ TPCRH 61_ QSPEI 66_ VREFL 71_ TALKS 76_ HKLTK 81_ AEKLQ 86_ LLNHR 91_ PVTAV 96_ EIQLM 101_ VEESE 106_ ERLTE 111_ EQIEA 116_ LLHTV 121_ TSILP 126_ AEPEA 131_ EQKKN 136_ TNSNV 141_AMDEE
1: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (PubMed:20413673, PubMed:33558764, PubMed:34675218). Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. With POLR3H/RPC8 forms a mobile stalk that protrudes from Pol III core and functions primarily in transcription initiation (By similarity) (PubMed:20413673, PubMed:33558764, PubMed:33558766, PubMed:34675218). Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway (PubMed:19609254, PubMed:19631370)
2: Accessory protein for the calcitonin gene-related peptide (CGRP) receptor. It modulates CGRP responsiveness in a variety of tissues