Low-density lipoprotein receptor-related protein 6 (LRP-6)
1_MGAVL 6_ RSLLA 11_ CSFCV 16_ LLRAA 21_ PLLLY 26_ ANRRD 31_ LRLVD 36_ ATNGK 41_ ENATI 46_ VVGGL 51_ EDAAA 56_ VDFVF 61_ SHGLI 66_ YWSDV 71_ SEEAI 76_ KRTEF 81_ NKTES 86_ VQNVV 91_ VSGLL 96_ SPDGL 101_ ACDWL 106_ GEKLY 111_ WTDSE 116_ TNRIE 121_ VSNLD 126_ GSLRK 131_ VLFWQ 136_ ELDQP 141_ RAIAL 146_ DPSSG 151_ FMYWT 156_ DWGEV 161_ PKIER 166_ AGMDG 171_ SSRFI 176_ IINSE 181_ IYWPN 186_ GLTLD 191_ YEEQK 196_ LYWAD 201_ AKLNF 206_ IHKSN 211_ LDGTN 216_ RQAVV 221_ KGSLP 226_ HPFAL 231_ TLFED 236_ ILYWT 241_ DWSTH 246_ SILAC 251_ NKYTG 256_ EGLRE 261_ IHSDI 266_ FSPMD 271_ IHAFS 276_ QQRQP 281_ NATNP 286_ CGIDN 291_ GGCSH 296_ LCLMS 301_ PVKPF 306_ YQCAC 311_ PTGVK 316_ LLENG 321_ KTCKD 326_ GATEL 331_ LLLAR 336_ RTDLR 341_ RISLD 346_ TPDFT 351_ DIVLQ 356_ LEDIR 361_ HAIAI 366_ DYDPV 371_ EGYIY 376_ WTDDE 381_ VRAIR 386_ RSFID 391_ GSGSQ 396_ FVVTA 401_ QIAHP 406_ DGIAV 411_ DWVAR 416_ NLYWT 421_ DTGTD 426_ RIEVT 431_ RLNGT 436_ MRKIL 441_ ISEDL 446_ EEPRA 451_ IVLDP 456_ MVGYM 461_ YWTDW 466_ GEIPK 471_ IERAA 476_ LDGSD 481_ RVVLV 486_ NTSLG 491_ WPNGL 496_ ALDYD 501_ EGKIY 506_ WGDAK 511_ TDKIE 516_ VMNTD 521_ GTGRR 526_ VLVED 531_ KIPHI 536_ FGFTL 541_ LGDYV 546_ YWTDW 551_ QRRSI 556_ ERVHK 561_ RSAER 566_ EVIID 571_ QLPDL 576_ MGLKA 581_ TNVHR 586_ VIGSN 591_ PCAEE 596_ NGGCS 601_ HLCLY 606_ RPQGL 611_ RCACP 616_ IGFEL 621_ ISDMK 626_ TCIVP 631_ EAFLL 636_ FSRRA 641_ DIRRI 646_ SLETN 651_ NNNVA 656_ IPLTG 661_ VKEAS 666_ ALDFD 671_ VTDNR 676_ IYWTD 681_ ISLKT 686_ ISRAF 691_ MNGSA 696_ LEHVV 701_ EFGLD 706_ YPEGM 711_ AVDWL 716_ GKNLY 721_ WADTG 726_ TNRIE 731_ VSKLD 736_ GQHRQ 741_ VLVWK 746_ DLDSP 751_ RALAL 756_ DPAEG 761_ FMYWT 766_ EWGGK 771_ PKIDR 776_ AAMDG 781_ SERTT 786_ LVPNV 791_ GRANG 796_ LTIDY 801_ AKRRL 806_ YWTDL 811_ DTNLI 816_ ESSNM 821_ LGLNR 826_ EVIAD 831_ DLPHP 836_ FGLTQ 841_ YQDYI 846_ YWTDW 851_ SRRSI 856_ ERANK 861_ TSGQN 866_ RTIIQ 871_ GHLDY 876_ VMDIL 881_ VFHSS 886_ RQSGW 891_ NECAS 896_ SNGHC 901_ SHLCL 906_ AVPVG 911_ GFVCG 916_ CPAHY 921_ SLNAD 926_ NRTCS 931_ APTTF 936_ LLFSQ 941_ KSAIN 946_ RMVID 951_ EQQSP 956_ DIILP 961_ IHSLR 966_ NVRAI 971_ DYDPL 976_ DKQLY 981_ WIDSR 986_ QNMIR 991_ KAQED 996_ GSQGF 1001_ TVVVS 1006_ SVPSQ 1011_ NLEIQ 1016_ PYDLS 1021_ IDIYS 1026_ RYIYW 1031_ TCEAT 1036_ NVINV 1041_ TRLDG 1046_ RSVGV 1051_ VLKGE 1056_ QDRPR 1061_ AVVVN 1066_ PEKGY 1071_ MYFTN 1076_ LQERS 1081_ PKIER 1086_ AALDG 1091_ TEREV 1096_ LFFSG 1101_ LSKPI 1106_ ALALD 1111_ SRLGK 1116_ LFWAD 1121_ SDLRR 1126_ IESSD 1131_ LSGAN 1136_ RIVLE 1141_ DSNIL 1146_ QPVGL 1151_ TVFEN 1156_ WLYWI 1161_ DKQQQ 1166_ MIEKI 1171_ DMTGR 1176_ EGRTK 1181_ VQARI 1186_ AQLSD 1191_ IHAVK 1196_ ELNLQ 1201_ EYRQH 1206_ PCAQD 1211_ NGGCS 1216_ HICLV 1221_ KGDGT 1226_ TRCSC 1231_ PMHLV 1236_ LLQDE 1241_ LSCGE 1246_ PPTCS 1251_ PQQFT 1256_ CFTGE 1261_ IDCIP 1266_ VAWRC 1271_ DGFTE 1276_ CEDHS 1281_ DELNC 1286_ PVCSE 1291_ SQFQC 1296_ ASGQC 1301_ IDGAL 1306_ RCNGD 1311_ ANCQD 1316_ KSDEK 1321_ NCEVL 1326_ CLIDQ 1331_ FRCAN 1336_ GQCIG 1341_ KHKKC 1346_ DHNVD 1351_ CSDKS 1356_ DELDC 1361_ YPTEE 1366_ PAPQA 1371_ TNTVG 1376_ SVIGV 1381_ IVTIF 1386_ VSGTV 1391_ YFICQ 1396_ RMLCP 1401_ RMKGD 1406_ GETMT 1411_ NDYVV 1416_ HGPAS 1421_ VPLGY 1426_ VPHPS 1431_ SLSGS 1436_ LPGMS 1441_ RGKSM 1446_ ISSLS 1451_ IMGGS 1456_ SGPPY 1461_ DRAHV 1466_ TGASS 1471_ SSSSS 1476_ TKGTY 1481_ FPAIL 1486_ NPPPS 1491_ PATER 1496_ SHYTM 1501_ EFGYS 1506_ SNSPS 1511_ THRSY 1516_ SYRPY 1521_ SYRHF 1526_ APPTT 1531_ PCSTD 1536_ VCDSD 1541_ YAPSR 1546_ RMTSV 1551_ ATAKG 1556_ YTSDL 1561_ NYDSE 1566_ PVPPP 1571_ PTPRS 1576_ QYLSA 1581_ EENYE 1586_ SCPPS 1591_ PYTER 1596_ SYSHH 1601_ LYPPP 1606_PSPCT
1: Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes (PubMed:11357136, PubMed:11448771, PubMed:15778503, PubMed:16341017, PubMed:16513652, PubMed:17326769, PubMed:17400545, PubMed:19107203, PubMed:19293931, PubMed:19801552, PubMed:28341812). Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation (PubMed:11357136, PubMed:11448771, PubMed:15778503, PubMed:16341017, PubMed:16513652, PubMed:17326769, PubMed:17400545, PubMed:19107203, PubMed:19293931, PubMed:19801552, PubMed:28341812). The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalosomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin (PubMed:16513652). Required for posterior patterning of the epiblast during gastrulation (By similarity)