Ribosomal protein S6 kinase alpha-5 (S6K-alpha-5) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 5) (Nuclear mitogen- and stress-activated protein kinase 1) (RSK-like protein kinase) (RSKL)
1_MEEEG 6_ GSSGG 11_ AAGTS 16_ ADGGD 21_ GGEQL 26_ LTVKH 31_ ELRTA 36_ NLTGH 41_ AEKVG 46_ IENFE 51_ LLKVL 56_ GTGAY 61_ GKVFL 66_ VRKIS 71_ GHDTG 76_ KLYAM 81_ KVLKK 86_ ATIVQ 91_ KAKTT 96_ EHTRT 101_ ERQVL 106_ EHIRQ 111_ SPFLV 116_ TLHYA 121_ FQTET 126_ KLHLI 131_ LDYIN 136_ GGELF 141_ THLSQ 146_ RERFT 151_ EHEVQ 156_ IYVGE 161_ IVLAL 166_ EHLHK 171_ LGIIY 176_ RDIKL 181_ ENILL 186_ DSNGH 191_ VVLTD 196_ FGLSK 201_ EFVAD 206_ ETERA 211_ YSFCG 216_ TIEYM 221_ APDIV 226_ RGGDS 231_ GHDKA 236_ VDWWS 241_ LGVLM 246_ YELLT 251_ GASPF 256_ TVDGE 261_ KNSQA 266_ EISRR 271_ ILKSE 276_ PPYPQ 281_ EMSAL 286_ AKDLI 291_ QRLLM 296_ KDPKK 301_ RLGCG 306_ PRDAD 311_ EIKEH 316_ LFFQK 321_ INWDD 326_ LAAKK 331_ VPAPF 336_ KPVIR 341_ DELDV 346_ SNFAE 351_ EFTEM 356_ DPTYS 361_ PAALP 366_ QSSEK 371_ LFQGY 376_ SFVAP 381_ SILFK 386_ RNAAV 391_ IDPLQ 396_ FHMGV 401_ ERPGV 406_ TNVAR 411_ SAMMK 416_ DSPFY 421_ QHYDL 426_ DLKDK 431_ PLGEG 436_ SFSIC 441_ RKCVH 446_ KKSNQ 451_ AFAVK 456_ IISKR 461_ MEANT 466_ QKEIT 471_ ALKLC 476_ EGHPN 481_ IVKLH 486_ EVFHD 491_ QLHTF 496_ LVMEL 501_ LNGGE 506_ LFERI 511_ KKKKH 516_ FSETE 521_ ASYIM 526_ RKLVS 531_ AVSHM 536_ HDVGV 541_ VHRDL 546_ KPENL 551_ LFTDE 556_ NDNLE 561_ IKIID 566_ FGFAR 571_ LKPPD 576_ NQPLK 581_ TPCFT 586_ LHYAA 591_ PELLN 596_ QNGYD 601_ ESCDL 606_ WSLGV 611_ ILYTM 616_ LSGQV 621_ PFQSH 626_ DRSLT 631_ CTSAV 636_ EIMKK 641_ IKKGD 646_ FSFEG 651_ EAWKN 656_ VSQEA 661_ KDLIQ 666_ GLLTV 671_ DPNKR 676_ LKMSG 681_ LRYNE 686_ WLQDG 691_ SQLSS 696_ NPLMT 701_ PDILG 706_ SSGAA 711_ VHTCV 716_ KATFH 721_ AFNKY 726_ KREGF 731_ CLQNV 736_ DKAPL 741_ AKRRK 746_ MKKTS 751_ TSTET 756_ RSSSS 761_ ESSHS 766_ SSSHS 771_ HGKTT 776_ PTKTL 781_ QPSNP 786_ ADSNN 791_ PETLF 796_QFSDS
1: Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes (PubMed:11909979, PubMed:12569367, PubMed:12763138, PubMed:18511904, PubMed:9687510, PubMed:9873047). Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin (PubMed:11909979, PubMed:9873047). Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression (PubMed:12628924, PubMed:18511904). In skeletal myoblasts is required for phosphorylation of RELA at 'Ser-276' during oxidative stress (PubMed:12628924). In erythropoietin-stimulated cells, is necessary for the 'Ser-727' phosphorylation of STAT3 and regulation of its transcriptional potential (PubMed:12763138). Phosphorylates ETV1/ER81 at 'Ser-191' and 'Ser-216', and thereby regulates its ability to stimulate transcription, which may be important during development and breast tumor formation (PubMed:12569367). Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A (PubMed:15010469). Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN (PubMed:12773393). May also phosphorylate 'Ser-28' of histone H3 (PubMed:12773393). Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14) (PubMed:12773393). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines (By similarity). Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors (By similarity). Plays a role in neuronal cell death by mediating the downstream effects of excitotoxic injury (By similarity). Phosphorylates TRIM7 at 'Ser-107' in response to growth factor signaling via the MEK/ERK pathway, thereby stimulating its ubiquitin ligase activity (PubMed:25851810)