Mediator of RNA polymerase II transcription subunit 6 (Activator-recruited cofactor 33 kDa component) (ARC33) (Mediator complex subunit 6) (hMed6) (Renal carcinoma antigen NY-REN-28)
1_MAAVD 6_ IRDNL 11_ LGISW 16_ VDSSW 21_ IPILN 26_ SGSVL 31_ DYFSE 36_ RSNPF 41_ YDRTC 46_ NNEVV 51_ KMQRL 56_ TLEHL 61_ NQMVG 66_ IEYIL 71_ LHAQE 76_ PILFI 81_ IRKQQ 86_ RQSPA 91_ QVIPL 96_ ADYYI 101_ IAGVI 106_ YQAPD 111_ LGSVI 116_ NSRVL 121_ TAVHG 126_ IQSAF 131_ DEAMS 136_ YCRYH 141_ PSKGY 146_ WWHFK 151_ DHEEQ 156_ DKVRP 161_ KAKRK 166_ EEPSS 171_ IFQRQ 176_ RVDAL 181_ LLDLR 186_ QKFPP 191_ KFVQL 196_ KPGEK 201_ PVPVD 206_ QTKKE 211_ AEPIP 216_ ETVKP 221_ EEKET 226_ TKNVQ 231_ QTVSA 236_ KGPPE 241_KRMRL
1: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors