E3 ubiquitin-protein ligase MYCBP2 (EC 2.3.2.33) (Myc-binding protein 2) (Protein associated with Myc)
1_MMMCA 6_ ATASP 11_ AAASS 16_ GLGGD 21_ GFYPA 26_ ATFSS 31_ SPAPG 36_ ALFMP 41_ VPDGS 46_ VAAAG 51_ LGLGL 56_ PAADS 61_ RGHYQ 66_ LLLSG 71_ RALAD 76_ RYRRI 81_ YTAAL 86_ NDRDQ 91_ GGGSA 96_ GHPAS 101_ RNKKI 106_ LNKKK 111_ LKRKQ 116_ KSKSK 121_ VKTRS 126_ KSENL 131_ ENTVI 136_ IPDIK 141_ LHSNP 146_ SAFNI 151_ YCNVR 156_ HCVLE 161_ WQKKE 166_ ISLAA 171_ ASKNS 176_ VQSGE 181_ SDSDE 186_ EEESK 191_ EPPIK 196_ LPKII 201_ EVGLC 206_ EVFEL 211_ IKETR 216_ FSHPS 221_ LCLRS 226_ LQALL 231_ NVLQG 236_ QQPEG 241_ LQSEP 246_ PEVLE 251_ SLFQL 256_ LLEIT 261_ VRSTG 266_ MNDST 271_ GQSLT 276_ ALSCA 281_ CLFSL 286_ VASWG 291_ ETGRT 296_ LQAIS 301_ AILTN 306_ NGSHA 311_ CQTIQ 316_ VPTIL 321_ NSLQR 326_ SVQAV 331_ LVGKI 336_ QIQDW 341_ FSNGI 346_ KKAAL 351_ MHKWP 356_ LKEIS 361_ VDEDD 366_ QCLLQ 371_ NDGFF 376_ LYLLC 381_ KDGLY 386_ KIGSG 391_ YSGTV 396_ RGHIY 401_ NSTSR 406_ IRNRK 411_ EKKSW 416_ LGYAQ 421_ GYLLY 426_ RDVNN 431_ HSMTA 436_ IRISP 441_ ETLEQ 446_ DGTVM 451_ LPDCH 456_ TEGQN 461_ ILFTD 466_ GEYIN 471_ QIAAS 476_ RDDGF 481_ VVRIF 486_ ATSTE 491_ PVLQQ 496_ ELQLK 501_ LARKC 506_ LHACG 511_ ISLFD 516_ LEKDL 521_ HIIST 526_ GFDEE 531_ SAILG 536_ AGREF 541_ ALMKT 546_ ANGKI 551_ YYTGK 556_ YQSLG 561_ IKQGG 566_ PSAGK 571_ WVELP 576_ ITKSP 581_ KIVHF 586_ SVGHD 591_ GSHAL 596_ LVAED 601_ GSIFF 606_ TGSAS 611_ KGEDG 616_ ESTKS 621_ RRQSK 626_ PYKPK 631_ KIIKM 636_ EGKIV 641_ VYTAC 646_ NNGSS 651_ SVISK 656_ DGELY 661_ MFGKD 666_ AIYSD 671_ SSSLV 676_ TDLKG 681_ HFVTQ 686_ VAMGK 691_ AHTCV 696_ LMKNG 701_ EVWTF 706_ GVNNK 711_ GQCGR 716_ DTGAM 721_ NQGGK 726_ GFGVE 731_ NMATA 736_ MDEDL 741_ EEELD 746_ EKDEK 751_ SMMCP 756_ PGMHK 761_ WKLEQ 766_ CMVCT 771_ VCGDC 776_ TGYGA 781_ SCVSS 786_ GRPDR 791_ VPGGI 796_ CGCGS 801_ GESGC 806_ AVCGC 811_ CKACA 816_ RELDG 821_ QEARQ 826_ RGILD 831_ AVKEM 836_ IPLDL 841_ LLAVP 846_ VPGVN 851_ IEEHL 856_ QLRQE 861_ EKRQR 866_ VIRRH 871_ RLEEG 876_ RGPLV 881_ FAGPI 886_ FMNHR 891_ EQALA 896_ RLRSH 901_ PAQLK 906_ HKRDK 911_ HKDGS 916_ GERGE 921_ KDASK 926_ ITTYP 931_ PGSVR 936_ FDCEL 941_ RAVQV 946_ SCGFH 951_ HSVVL 956_ MENGD 961_ VYTFG 966_ YGQHG 971_ QLGHG 976_ DVNSR 981_ GCPTL 986_ VQALP 991_ GPSTQ 996_ VTAGS 1001_ NHTAV 1006_ LLMDG 1011_ QVFTF 1016_ GSFSK 1021_ GQLGR 1026_ PILDV 1031_ PYWNA 1036_ KPAPM 1041_ PNIGS 1046_ KYGRK 1051_ ATWIG 1056_ ASGDQ 1061_ TFLRI 1066_ DEALI 1071_ NSHVL 1076_ ATSEI 1081_ FASKH 1086_ IIGLV 1091_ PASIS 1096_ EPPPF 1101_ KCLLI 1106_ NKVDG 1111_ SCKTF 1116_ NDSEQ 1121_ EDLQG 1126_ FGVCL 1131_ DPVYD 1136_ VIWRF 1141_ RPNTR 1146_ ELWCY 1151_ NAVVA 1156_ DARLP 1161_ SAADM 1166_ QSRCS 1171_ ILSPE 1176_ LALPT 1181_ GSRAL 1186_ TTRSH 1191_ AALHI 1196_ LGCLD 1201_ TLAAM 1206_ QDLKM 1211_ GVAST 1216_ EEETQ 1221_ AVMKV 1226_ YSKED 1231_ YSVVN 1236_ RFESH 1241_ GGGWG 1246_ YSAHS 1251_ VEAIR 1256_ FSADT 1261_ DILLG 1266_ GLGLF 1271_ GGRGE 1276_ YTAKI 1281_ KLFEL 1286_ GPDGG 1291_ DHETD 1296_ GDLLA 1301_ ETDVL 1306_ AYDCA 1311_ AREKY 1316_ AMMFD 1321_ EPVLL 1326_ QAGWW 1331_ YVAWA 1336_ RVSGP 1341_ SSDCG 1346_ SHGQA 1351_ SITTD 1356_ DGVVF 1361_ QFKSS 1366_ KKSNN 1371_ GTDVN 1376_ AGQIP 1381_ QLLYR 1386_ LPTSD 1391_ GSASK 1396_ GKQQT 1401_ SEPVH 1406_ ILKRS 1411_ FARTV 1416_ SVECF 1421_ ESLLS 1426_ ILHWS 1431_ WTTLV 1436_ LGVEE 1441_ LRGLK 1446_ GFQFT 1451_ ATLLD 1456_ LERLR 1461_ FVGTC 1466_ CLRLL 1471_ RVYTC 1476_ EIYPV 1481_ SATGK 1486_ AVVEE 1491_ TSKLA 1496_ ECIGK 1501_ TRTLL 1506_ RKILS 1511_ EGVDH 1516_ CMVKL 1521_ DNDPQ 1526_ GYLSQ 1531_ PLSLL 1536_ EAVLQ 1541_ ECHNT 1546_ FTACF 1551_ HSFYP 1556_ TPALQ 1561_ WACLC 1566_ DLLNC 1571_ LDQDI 1576_ QEANF 1581_ KTSSS 1586_ RLLAA 1591_ VMSAL 1596_ CHTSV 1601_ KLTSI 1606_ FPIAY 1611_ DGEVL 1616_ LRSIV 1621_ KQVST 1626_ ENDST 1631_ LVHRF 1636_ PLLVA 1641_ HMEKL 1646_ SQSEE 1651_ NISGM 1656_ TSFRE 1661_ VLEKM 1666_ LVIVV 1671_ LPVRN 1676_ SLRRE 1681_ NELFS 1686_ SHLVS 1691_ NTCGL 1696_ LASIV 1701_ SELTA 1706_ SALGS 1711_ EVDGL 1716_ NSLHS 1721_ VKASA 1726_ NRFTK 1731_ TSQGR 1736_ SWNTG 1741_ NGSPD 1746_ AICFS 1751_ VDKPG 1756_ IVVVG 1761_ FSVYG 1766_ GGGIH 1771_ EYELE 1776_ VLVDD 1781_ SEHAG 1786_ DSTHS 1791_ HRWTS 1796_ LELVK 1801_ GTYTT 1806_ DDSPS 1811_ DIAEI 1816_ RLDKV 1821_ VPLKE 1826_ NVKYA 1831_ VRLRN 1836_ YGSRT 1841_ ANGDG 1846_ GMTTV 1851_ QCPDG 1856_ VTFTF 1861_ STCSL 1866_ SSNGT 1871_ NQTRG 1876_ QIPQI 1881_ LYYRS 1886_ EFDGD 1891_ LQSQL 1896_ LSKAN 1901_ EEDKN 1906_ CSRAL 1911_ SVVST 1916_ VVRAS 1921_ KDLLH 1926_ RALAV 1931_ DADDI 1936_ PELLS 1941_ SSSLF 1946_ SMLLP 1951_ LIIAY 1956_ IGPVA 1961_ AAIPK 1966_ VAVEV 1971_ FGLVQ 1976_ QLLPS 1981_ VAILN 1986_ QKYAP 1991_ PAFNP 1996_ NQSTD 2001_ STTGN 2006_ QPEQG 2011_ LSACT 2016_ TSSHY 2021_ AVIES 2026_ EHPYK 2031_ PACVM 2036_ HYKVT 2041_ FPECV 2046_ RWMTI 2051_ EFDPQ 2056_ CGTAQ 2061_ SEDVL 2066_ RLLIP 2071_ VRTVQ 2076_ NSGYG 2081_ PKLTS 2086_ VHENL 2091_ NSWIE 2096_ LKKFS 2101_ GSSGW 2106_ PTMVL 2111_ VLPGN 2116_ EALFS 2121_ LETAS 2126_ DYVKD 2131_ DKASF 2136_ YGFKC 2141_ FAIGY 2146_ EFSPG 2151_ PDEGV 2156_ IQLEK 2161_ ELANL 2166_ GGVCA 2171_ AALMK 2176_ KDLAL 2181_ PIGNE 2186_ LEEDL 2191_ EILEE 2196_ AALQV 2201_ CKTHS 2206_ GILGK 2211_ GLALS 2216_ HSPTI 2221_ LEALE 2226_ GNLPL 2231_ QIQSN 2236_ EQSFL 2241_ DDFIA 2246_ CVPGS 2251_ SGGRL 2256_ ARWLQ 2261_ PDSYA 2266_ DPQKT 2271_ SLILN 2276_ KDDIR 2281_ CGWPT 2286_ TITVQ 2291_ TKDQY 2296_ GDVVH 2301_ VPNMK 2306_ VEVKA 2311_ VPVSQ 2316_ KKMSL 2321_ QQDQA 2326_ KKPQR 2331_ IPGSP 2336_ AVTAA 2341_ SSNTD 2346_ MTYGG 2351_ LASPK 2356_ LDVSY 2361_ EPMIV 2366_ KEARY 2371_ IAITM 2376_ MKVYE 2381_ NYSFE 2386_ ELRFA 2391_ SPTPK 2396_ RPSEN 2401_ MLIRV 2406_ NNDGT 2411_ YCANW 2416_ TPGAI 2421_ GLYTL 2426_ HVTID 2431_ GIEID 2436_ AGLEV 2441_ KVKDP 2446_ PKGMI 2451_ PPGTQ 2456_ LVKPK 2461_ SEPQP 2466_ NKVRK 2471_ FVAKD 2476_ SAGLR 2481_ IRSHP 2486_ SLQSE 2491_ QIGIV 2496_ KVNGT 2501_ ITFID 2506_ EIHND 2511_ DGVWL 2516_ RLNDE 2521_ TIKKY 2526_ VPNMN 2531_ GYTEA 2536_ WCLSF 2541_ NQHLG 2546_ KSLLV 2551_ PVDES 2556_ KTNTD 2561_ DFFKD 2566_ INSCC 2571_ PQEAT 2576_ MQEQD 2581_ MPFLR 2586_ GGPGM 2591_ YKVVK 2596_ TGPSG 2601_ HNIRS 2606_ CPNLR 2611_ GIPIG 2616_ MLVLG 2621_ NKVKA 2626_ VGEVT 2631_ NSEGT 2636_ WVQLD 2641_ QNSMV 2646_ EFCES 2651_ DEGEA 2656_ WSLAR 2661_ DRGGN 2666_ QYLRH 2671_ EDEQA 2676_ LLDQN 2681_ SQTPP 2686_ PSPFS 2691_ VQAFN 2696_ KGASC 2701_ SAQGF 2706_ DYGLG 2711_ NSKGD 2716_ RGNIS 2721_ TSSKP 2726_ ASTSG 2731_ KSELS 2736_ SKHSR 2741_ SLKPD 2746_ GRMSR 2751_ TTADQ 2756_ KKPRG 2761_ TESLS 2766_ ASESL 2771_ ILKSD 2776_ AAKLR 2781_ SDSHS 2786_ RSLSP 2791_ NHNTL 2796_ QTLKS 2801_ DGRMP 2806_ SSSRA 2811_ ESPGP 2816_ GSRLS 2821_ SPKPK 2826_ TLPAN 2831_ RSSPS 2836_ GASSP 2841_ RSSSP 2846_ HDKNL 2851_ PQKST 2856_ APVKT 2861_ KLDPP 2866_ RERSK 2871_ SDSYT 2876_ LDPDT 2881_ LRKKK 2886_ MPLTE 2891_ PLRGR 2896_ STSPK 2901_ PKSVP 2906_ KDSTD 2911_ SPGSE 2916_ NRAPS 2921_ PHVVQ 2926_ ENLHS 2931_ EVVEV 2936_ CTSST 2941_ LKTNS 2946_ LTDST 2951_ CDDSS 2956_ EFKSV 2961_ DEGSN 2966_ KVHFS 2971_ IGKAP 2976_ LKDEQ 2981_ EMRAS 2986_ PKISR 2991_ KCANR 2996_ HTRPK 3001_ KEKSS 3006_ FLFKG 3011_ DGSKP 3016_ LEPAK 3021_ QAMSP 3026_ SVAEC 3031_ ARAVF 3036_ ASFLW 3041_ HEGIV 3046_ HDAMA 3051_ CSSFL 3056_ KFHPE 3061_ LSKEH 3066_ APIRS 3071_ SLNSQ 3076_ QPTEE 3081_ KETKL 3086_ KNRHS 3091_ LEISS 3096_ ALNMF 3101_ NIAPH 3106_ GPDIS 3111_ KMGSI 3116_ NKNKV 3121_ LSMLK 3126_ EPPLH 3131_ EKCED 3136_ GKTET 3141_ TFEMS 3146_ MHNTM 3151_ KSKSP 3156_ LPLTL 3161_ QHLVA 3166_ FWEDI 3171_ SLATI 3176_ KAASQ 3181_ NMIFP 3186_ SPGSC 3191_ AVLKK 3196_ KECEK 3201_ ENKKS 3206_ KKEKK 3211_ KKEKA 3216_ EVRPR 3221_ GNLFG 3226_ EMAQL 3231_ AVGGP 3236_ EKDTI 3241_ CELCG 3246_ ESHPY 3251_ PVTYH 3256_ MRQAH 3261_ PGCGR 3266_ YAGGQ 3271_ GYNSI 3276_ GHFCG 3281_ GWAGN 3286_ CGDGG 3291_ IGGST 3296_ WYLVC 3301_ DRCRE 3306_ KYLRE 3311_ KQAAA 3316_ REKVK 3321_ QSRRK 3326_ PMQVK 3331_ TPRAL 3336_ PTMEA 3341_ HQVIK 3346_ ANALF 3351_ LLSLS 3356_ SAAEP 3361_ SILCY 3366_ HPAKP 3371_ FQSQL 3376_ PSVKE 3381_ GISED 3386_ LPVKM 3391_ PCLYL 3396_ QTLAR 3401_ HHHEN 3406_ FVGYQ 3411_ DDNLF 3416_ QDEMR 3421_ YLRST 3426_ SVPAP 3431_ YISVT 3436_ PDASP 3441_ NVFEE 3446_ PESNM 3451_ KSMPP 3456_ SLETS 3461_ PITDT 3466_ DLAKR 3471_ TVFQR 3476_ SYSVV 3481_ ASEYD 3486_ KQHSI 3491_ LPARV 3496_ KAIPR 3501_ RRVNS 3506_ GDTEV 3511_ GSSLL 3516_ RHPSP 3521_ ELSRL 3526_ ISAHS 3531_ SLSKG 3536_ ERNFQ 3541_ WPVLA 3546_ FVIQH 3551_ HDLEG 3556_ LEIAM 3561_ KQALR 3566_ KSACR 3571_ VFAME 3576_ AFNWL 3581_ LCNVI 3586_ QTTSL 3591_ HDILW 3596_ HFVAS 3601_ LTPAP 3606_ VEPEE 3611_ EEDEE 3616_ NKTSK 3621_ ENSEQ 3626_ EKDTR 3631_ VCEHP 3636_ LSDIV 3641_ IAGEA 3646_ AHPLP 3651_ HTFHR 3656_ LLQTI 3661_ SDLMM 3666_ SLPSG 3671_ SSLQQ 3676_ MALRC 3681_ WSLKF 3686_ KQSDH 3691_ QFLHQ 3696_ SNVFH 3701_ HINNI 3706_ LSKSD 3711_ DGDSE 3716_ ESFSI 3721_ SIQSG 3726_ FEAMS 3731_ QELCI 3736_ VMCLK 3741_ DLTSI 3746_ VDIKT 3751_ SSRPA 3756_ MIGSL 3761_ TDGST 3766_ ETFWE 3771_ SGDED 3776_ KNKTK 3781_ NITIN 3786_ CVKGI 3791_ NARYV 3796_ SVHVD 3801_ NSRDL 3806_ GNKVT 3811_ SMTFL 3816_ TGKAV 3821_ EDLCR 3826_ IKQVD 3831_ LDSRH 3836_ IGWVT 3841_ SELPG 3846_ GDNHI 3851_ IKIEL 3856_ KGPEN 3861_ TLRVR 3866_ QVKVL 3871_ GWKDG 3876_ ESTKI 3881_ AGQIS 3886_ ASVAQ 3891_ QRNCE 3896_ AETLR 3901_ VFRLI 3906_ TSQVF 3911_ GKLIS 3916_ GDAEP 3921_ TPEQE 3926_ EKALL 3931_ SSPEG 3936_ EEKVY 3941_ NATSD 3946_ ADLKE 3951_ HMVGI 3956_ IFSRS 3961_ KLTNL 3966_ QKQVC 3971_ AHIVQ 3976_ AIRME 3981_ ATRVR 3986_ EEWEH 3991_ AISSK 3996_ ENANS 4001_ QPNDE 4006_ DASSD 4011_ AYCFE 4016_ LLSMV 4021_ LALSG 4026_ SNVGR 4031_ QYLAQ 4036_ QLTLL 4041_ QDLFS 4046_ LLHTA 4051_ SPRVQ 4056_ RQVTS 4061_ LLRRV 4066_ LPEVT 4071_ PSRLA 4076_ SIIGV 4081_ KSLPP 4086_ ADISD 4091_ IIHST 4096_ EKGDW 4101_ NKLGI 4106_ LDMFL 4111_ GCIAK 4116_ ALTVQ 4121_ LKAKG 4126_ TTITG 4131_ TAGTT 4136_ VGKGV 4141_ TTVTL 4146_ PMIFN 4151_ SSYLR 4156_ RGESH 4161_ WWMKG 4166_ STPTQ 4171_ ISEII 4176_ IKLIK 4181_ DMAAG 4186_ HLSEA 4191_ WSRVT 4196_ KNAIA 4201_ ETIIA 4206_ LTKME 4211_ EEFRS 4216_ PVRCI 4221_ ATTRL 4226_ WLALA 4231_ SLCVL 4236_ DQDHV 4241_ DRLSS 4246_ GRWMG 4251_ KDGQQ 4256_ KQMPM 4261_ CDNHD 4266_ DGETA 4271_ AIILC 4276_ NVCGN 4281_ LCTDC 4286_ DRFLH 4291_ LHRRT 4296_ KTHQR 4301_ QVFKE 4306_ EEEAI 4311_ KVDLH 4316_ EGCGR 4321_ TKLFW 4326_ LMALA 4331_ DSKTM 4336_ KAMVE 4341_ FREHT 4346_ GKPTT 4351_ SSSEA 4356_ CRFCG 4361_ SRSGT 4366_ ELSAV 4371_ GSVCS 4376_ DADCQ 4381_ EYAKI 4386_ ACSKT 4391_ HPCGH 4396_ PCGGV 4401_ KNEEH 4406_ CLPCL 4411_ HGCDK 4416_ SATSL 4421_ KQDAD 4426_ DMCMI 4431_ CFTEA 4436_ LSAAP 4441_ AIQLD 4446_ CSHIF 4451_ HLQCC 4456_ RRVLE 4461_ NRWLG 4466_ PRITF 4471_ GFISC 4476_ PICKN 4481_ KINHI 4486_ VLKDL 4491_ LDPIK 4496_ ELYED 4501_ VRRKA 4506_ LMRLE 4511_ YEGLH 4516_ KSEAI 4521_ TTPGV 4526_ RFYND 4531_ PAGYA 4536_ MNRYA 4541_ YYVCY 4546_ KCRKA 4551_ YFGGE 4556_ ARCDA 4561_ EAGRG 4566_ DDYDP 4571_ RELIC 4576_ GACSD 4581_ VSRAQ 4586_ MCPKH 4591_ GTDFL 4596_ EYKCR 4601_ YCCSV 4606_ AVFFC 4611_ FGTTH 4616_ FCNAC 4621_ HDDFQ 4626_ RMTSI 4631_ PKEEL 4636_ PHCPA 4641_ GPKGK 4646_ QLEGT 4651_ ECPLH 4656_ VVHPP 4661_ TGEEF 4666_ ALGCG 4671_VCRNA
1: Atypical E3 ubiquitin-protein ligase which specifically mediates ubiquitination of threonine and serine residues on target proteins, instead of ubiquitinating lysine residues (PubMed:29643511). Shows esterification activity towards both threonine and serine, with a preference for threonine, and acts via two essential catalytic cysteine residues that relay ubiquitin to its substrate via thioester intermediates (PubMed:29643511). Interacts with the E2 enzymes UBE2D1, UBE2D3, UBE2E1 and UBE2L3 (PubMed:18308511, PubMed:29643511). Plays a key role in neural development, probably by mediating ubiquitination of threonine residues on target proteins (Probable). Involved in different processes such as regulation of neurite outgrowth, synaptic growth, synaptogenesis and axon degeneration (By similarity). Required for the formation of major central nervous system axon tracts (By similarity). Required for proper axon growth by regulating axon navigation and axon branching: acts by regulating the subcellular location and stability of MAP3K12/DLK (By similarity). Required for proper localization of retinogeniculate projections but not for eye-specific segregation (By similarity). Regulates axon guidance in the olfactory system (By similarity). Involved in Wallerian axon degeneration, an evolutionarily conserved process that drives the loss of damaged axons: acts by promoting destabilization of NMNAT2, probably via ubiquitination of NMNAT2 (By similarity). Catalyzes ubiquitination of threonine and/or serine residues on NMNAT2, consequences of threonine and/or serine ubiquitination are however unknown (PubMed:29643511). Regulates the internalization of TRPV1 in peripheral sensory neurons (By similarity). Mediates ubiquitination and subsequent proteasomal degradation of TSC2/tuberin (PubMed:18308511, PubMed:27278822). Independently of the E3 ubiquitin-protein ligase activity, also acts as a guanosine exchange factor (GEF) for RAN in neurons of dorsal root ganglia (PubMed:26304119). May function as a facilitator or regulator of transcriptional activation by MYC (PubMed:9689053). Acts in concert with HUWE1 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529)