Forkhead box protein H1 (Forkhead activin signal transducer 1) (Fast-1) (hFAST-1) (Forkhead activin signal transducer 2) (Fast-2)
1_MGPCS 6_ GSRLG 11_ PPEAE 16_ SPSQP 21_ PKRRK 26_ KRYLR 31_ HDKPP 36_ YTYLA 41_ MIALV 46_ IQAAP 51_ SRRLK 56_ LAQII 61_ RQVQA 66_ VFPFF 71_ REDYE 76_ GWKDS 81_ IRHNL 86_ SSNRC 91_ FRKVP 96_ KDPAK 101_ PQAKG 106_ NFWAV 111_ DVSLI 116_ PAEAL 121_ RLQNT 126_ ALCRR 131_ WQNGG 136_ ARGAF 141_ AKDLG 146_ PYVLH 151_ GRPYR 156_ PPSPP 161_ PPPSE 166_ GFSIK 171_ SLLGG 176_ SGEGA 181_ PWPGL 186_ APQSS 191_ PVPAG 196_ TGNSG 201_ EEAVP 206_ TPPLP 211_ SSERP 216_ LWPLC 221_ PLPGP 226_ TRVEG 231_ ETVQG 236_ GAIGP 241_ STLSP 246_ EPRAW 251_ PLHLL 256_ QGTAV 261_ PGGRS 266_ SGGHR 271_ ASLWG 276_ QLPTS 281_ YLPIY 286_ TPNVV 291_ MPLAP 296_ PPTSC 301_ PQCPS 306_ TSPAY 311_ WGVAP 316_ ETRGP 321_ PGLLC 326_ DLDAL 331_ FQGVP 336_ PNKSI 341_ YDVWV 346_ SHPRD 351_ LAAPG 356_PGWLL
1: Transcriptional activator. Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Required for induction of the goosecoid (GSC) promoter by TGF-beta or activin signaling. Forms a transcriptionally active complex containing FOXH1/SMAD2/SMAD4 on a site on the GSC promoter called TARE (TGF-beta/activin response element)