Ubiquitin carboxyl-terminal hydrolase 2 (EC 3.4.19.12) (41 kDa ubiquitin-specific protease) (Deubiquitinating enzyme 2) (Ubiquitin thioesterase 2) (Ubiquitin-specific-processing protease 2)
1_MSQLS 6_ STLKR 11_ YTESA 16_ RYTDA 21_ HYAKS 26_ GYGAY 31_ TPSSY 36_ GANLA 41_ ASLLE 46_ KEKLG 51_ FKPVP 56_ TSSFL 61_ TRPRT 66_ YGPSS 71_ LLDYD 76_ RGRPL 81_ LRPDI 86_ TGGGK 91_ RAESQ 96_ TRGTE 101_ RPLGS 106_ GLSGG 111_ SGFPY 116_ GVTNN 121_ CLSYL 126_ PINAY 131_ DQGVT 136_ LTQKL 141_ DSQSD 146_ LARDF 151_ SSLRT 156_ SDSYR 161_ IDPRN 166_ LGRSP 171_ MLART 176_ RKELC 181_ TLQGL 186_ YQTAS 191_ CPEYL 196_ VDYLE 201_ NYGRK 206_ GSASQ 211_ VPSQA 216_ PPSRV 221_ PEIIS 226_ PTYRP 231_ IGRYT 236_ LWETG 241_ KGQAP 246_ GPSRS 251_ SSPGR 256_ DGMNS 261_ KSAQG 266_ LAGLR 271_ NLGNT 276_ CFMNS 281_ ILQCL 286_ SNTRE 291_ LRDYC 296_ LQRLY 301_ MRDLH 306_ HGSNA 311_ HTALV 316_ EEFAK 321_ LIQTI 326_ WTSSP 331_ NDVVS 336_ PSEFK 341_ TQIQR 346_ YAPRF 351_ VGYNQ 356_ QDAQE 361_ FLRFL 366_ LDGLH 371_ NEVNR 376_ VTLRP 381_ KSNPE 386_ NLDHL 391_ PDDEK 396_ GRQMW 401_ RKYLE 406_ REDSR 411_ IGDLF 416_ VGQLK 421_ SSLTC 426_ TDCGY 431_ CSTVF 436_ DPFWD 441_ LSLPI 446_ AKRGY 451_ PEVTL 456_ MDCMR 461_ LFTKE 466_ DVLDG 471_ DEKPT 476_ CCRCR 481_ GRKRC 486_ IKKFS 491_ IQRFP 496_ KILVL 501_ HLKRF 506_ SESRI 511_ RTSKL 516_ TTFVN 521_ FPLRD 526_ LDLRE 531_ FASEN 536_ TNHAV 541_ YNLYA 546_ VSNHS 551_ GTTMG 556_ GHYTA 561_ YCRSP 566_ GTGEW 571_ HTFND 576_ SSVTP 581_ MSSSQ 586_ VRTSD 591_ AYLLF 596_YELAS
1: Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1 (PubMed:17290220, PubMed:19838211, PubMed:19917254). Isoform 1 and isoform 4 possess both ubiquitin-specific peptidase and isopeptidase activities (By similarity). Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity (PubMed:17290220, PubMed:19838211). Has no deubiquitinase activity against p53/TP53 (PubMed:17290220). Prevents MDM2-mediated degradation of MDM4 (PubMed:17290220). Plays a role in the G1/S cell-cycle progression in normal and cancer cells (PubMed:19917254). Regulates the circadian clock by modulating its intrinsic circadian rhythm and its capacity to respond to external cues (By similarity). Associates with clock proteins and deubiquitinates core clock component PER1 but does not affect its overall stability (By similarity). Regulates the nucleocytoplasmic shuttling and nuclear retention of PER1 and its repressive role on the clock transcription factors CLOCK and BMAL1 (By similarity). Plays a role in the regulation of myogenic differentiation of embryonic muscle cells (By similarity)
2: Circadian clock output effector that regulates Ca(2+) absorption in the small intestine. Probably functions by regulating protein levels of the membrane scaffold protein NHERF4 in a rhythmic manner, and is therefore likely to control Ca(2+) membrane permeability mediated by the Ca(2+) channel TRPV6 in the intestine