Death effector domain-containing protein (DEDPro1) (Death effector domain-containing testicular molecule) (FLDED-1)
1_MAGLK 6_ RRASQ 11_ VWPEE 16_ HGEQE 21_ HGLYS 26_ LHRMF 31_ DIVGT 36_ HLTHR 41_ DVRVL 46_ SFLFV 51_ DVIDD 56_ HERGL 61_ IRNGR 66_ DFLLA 71_ LERQG 76_ RCDES 81_ NFRQV 86_ LQLLR 91_ IITRH 96_ DLLPY 101_ VTLKR 106_ RRAVC 111_ PDLVD 116_ KYLEE 121_ TSIRY 126_ VTPRA 131_ LSDPE 136_ PRPPQ 141_ PSKTV 146_ PPHYP 151_ VVCCP 156_ TSGPQ 161_ MCSKR 166_ PARGR 171_ ATLGS 176_ QRKRR 181_ KSVTP 186_ DPKEK 191_ QTCDI 196_ RLRVR 201_ AEYCQ 206_ HETAL 211_ QGNVF 216_ SNKQD 221_ PLERQ 226_ FERFN 231_ QANTI 236_ LKSRD 241_ LGSII 246_ CDIKF 251_ SELTY 256_ LDAFW 261_ RDYIN 266_ GSLLE 271_ ALKGV 276_ FITDS 281_ LKQAV 286_ GHEAI 291_ KLLVN 296_ VDEED 301_ YELGR 306_ QKLLR 311_NLMLQ
1: A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation during apoptosis. May also play a role in mediating CASP3 cleavage of KRT18. Regulates degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. Inhibits DNA transcription in vitro (By similarity)