PR domain zinc finger protein 1 (EC 2.1.1.-) (BLIMP-1) (Beta-interferon gene positive regulatory domain I-binding factor) (PR domain-containing protein 1) (Positive regulatory domain I-binding factor 1) (PRDI-BF1) (PRDI-binding factor 1)
1_MLDIC 6_ LEKRV 11_ GTTLA 16_ APKCN 21_ SSTVR 26_ FQGLA 31_ EGTKG 36_ TMKMD 41_ MEDAD 46_ MTLWT 51_ EAEFE 56_ EKCTY 61_ IVNDH 66_ PWDSG 71_ ADGGT 76_ SVQAE 81_ ASLPR 86_ NLLFK 91_ YATNS 96_ EEVIG 101_ VMSKE 106_ YIPKG 111_ TRFGP 116_ LIGEI 121_ YTNDT 126_ VPKNA 131_ NRKYF 136_ WRIYS 141_ RGELH 146_ HFIDG 151_ FNEEK 156_ SNWMR 161_ YVNPA 166_ HSPRE 171_ QNLAA 176_ CQNGM 181_ NIYFY 186_ TIKPI 191_ PANQE 196_ LLVWY 201_ CRDFA 206_ ERLHY 211_ PYPGE 216_ LTMMN 221_ LTQTQ 226_ SSLKQ 231_ PSTEK 236_ NELCP 241_ KNVPK 246_ REYSV 251_ KEILK 256_ LDSNP 261_ SKGKD 266_ LYRSN 271_ ISPLT 276_ SEKDL 281_ DDFRR 286_ RGSPE 291_ MPFYP 296_ RVVYP 301_ IRAPL 306_ PEDFL 311_ KASLA 316_ YGIER 321_ PTYIT 326_ RSPIP 331_ SSTTP 336_ SPSAR 341_ SSPDQ 346_ SLKSS 351_ SPHSS 356_ PGNTV 361_ SPVGP 366_ GSQEH 371_ RDSYA 376_ YLNAS 381_ YGTEG 386_ LGSYP 391_ GYAPL 396_ PHLPP 401_ AFIPS 406_ YNAHY 411_ PKFLL 416_ PPYGM 421_ NCNGL 426_ SAVSS 431_ MNGIN 436_ NFGLF 441_ PRLCP 446_ VYSNL 451_ LGGGS 456_ LPHPM 461_ LNPTS 466_ LPSSL 471_ PSDGA 476_ RRLLQ 481_ PEHPR 486_ EVLVP 491_ APHSA 496_ FSFTG 501_ AAASM 506_ KDKAC 511_ SPTSG 516_ SPTAG 521_ TAATA 526_ EHVVQ 531_ PKATS 536_ AAMAA 541_ PSSDE 546_ AMNLI 551_ KNKRN 556_ MTGYK 561_ TLPYP 566_ LKKQN 571_ GKIKY 576_ ECNVC 581_ AKTFG 586_ QLSNL 591_ KVHLR 596_ VHSGE 601_ RPFKC 606_ QTCNK 611_ GFTQL 616_ AHLQK 621_ HYLVH 626_ TGEKP 631_ HECQV 636_ CHKRF 641_ SSTSN 646_ LKTHL 651_ RLHSG 656_ EKPYQ 661_ CKVCP 666_ AKFTQ 671_ FVHLK 676_ LHKRL 681_ HTRER 686_ PHKCS 691_ QCHKN 696_ YIHLC 701_ SLKVH 706_ LKGNC 711_ AAAPA 716_ PGLPL 721_ EDLTR 726_ INEEI 731_ EKFDI 736_ SDNAD 741_ RLEDV 746_ EDDIS 751_ VISVV 756_ EKEIL 761_ AVVRK 766_ EKEET 771_ GLKVS 776_ LQRNM 781_ GNGLL 786_ SSGCS 791_ LYESS 796_ DLPLM 801_ KLPPS 806_ NPLPL 811_ VPVKV 816_KQETV
1: Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection (By similarity). Binds specifically to the PRDI element in the promoter of the beta-interferon gene (PubMed:1851123). Drives the maturation of B-lymphocytes into Ig secreting cells (PubMed:12626569). Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions (By similarity). Binds to the promoter and acts as a transcriptional repressor of IRF8, thereby promotes transcription of osteoclast differentiation factors such as NFATC1 and EEIG1 (By similarity)