U5 small nuclear ribonucleoprotein 200 kDa helicase (EC 3.6.4.13) (Activating signal cointegrator 1 complex subunit 3-like 1) (BRR2 homolog) (U5 snRNP-specific 200 kDa protein) (U5-200KD)
1_MADVT 6_ ARSLQ 11_ YEYKA 16_ NSNLV 21_ LQADR 26_ SLIDR 31_ TRRDE 36_ PTGEV 41_ LSLVG 46_ KLEGT 51_ RMGDK 56_ AQRTK 61_ PQMQE 66_ ERRAK 71_ RRKRD 76_ EDRHD 81_ INKMK 86_ GYTLL 91_ SEGID 96_ EMVGI 101_ IYKPK 106_ TKETR 111_ ETYEV 116_ LLSFI 121_ QAALG 126_ DQPRD 131_ ILCGA 136_ ADEVL 141_ AVLKN 146_ EKLRD 151_ KERRK 156_ EIDLL 161_ LGQTD 166_ DTRYH 171_ VLVNL 176_ GKKIT 181_ DYGGD 186_ KEIQN 191_ MDDNI 196_ DETYG 201_ VNVQF 206_ ESDEE 211_ EGDED 216_ VYGEV 221_ REEAS 226_ DDDME 231_ GDEAV 236_ VRCTL 241_ SANLV 246_ ASGEL 251_ MSSKK 256_ KDLHP 261_ RDIDA 266_ FWLQR 271_ QLSRF 276_ YDDAI 281_ VSQKK 286_ ADEVL 291_ EILKT 296_ ASDDR 301_ ECENQ 306_ LVLLL 311_ GFNTF 316_ DFIKV 321_ LRQHR 326_ MMILY 331_ CTLLA 336_ SAQSE 341_ AEKER 346_ IMGKM 351_ EADPE 356_ LSKFL 361_ YQLHE 366_ TEKED 371_ LIREE 376_ RSRRE 381_ RVRQS 386_ RMDTD 391_ LETMD 396_ LDQGG 401_ EALAP 406_ RQVLD 411_ LEDLV 416_ FTQGS 421_ HFMAN 426_ KRCQL 431_ PDGSF 436_ RRQRK 441_ GYEEV 446_ HVPAL 451_ KPKPF 456_ GSEEQ 461_ LLPVE 466_ KLPKY 471_ AQAGF 476_ EGFKT 481_ LNRIQ 486_ SKLYR 491_ AALET 496_ DENLL 501_ LCAPT 506_ GAGKT 511_ NVALM 516_ CMLRE 521_ IGKHI 526_ NMDGT 531_ INVDD 536_ FKIIY 541_ IAPMR 546_ SLVQE 551_ MVGSF 556_ GKRLA 561_ TYGIT 566_ VAELT 571_ GDHQL 576_ CKEEI 581_ SATQI 586_ IVCTP 591_ EKWDI 596_ ITRKG 601_ GERTY 606_ TQLVR 611_ LIILD 616_ EIHLL 621_ HDDRG 626_ PVLEA 631_ LVARA 636_ IRNIE 641_ MTQED 646_ VRLIG 651_ LSATL 656_ PNYED 661_ VATFL 666_ RVDPA 671_ KGLFY 676_ FDNSF 681_ RPVPL 686_ EQTYV 691_ GITEK 696_ KAIKR 701_ FQIMN 706_ EIVYE 711_ KIMEH 716_ AGKNQ 721_ VLVFV 726_ HSRKE 731_ TGKTA 736_ RAIRD 741_ MCLEK 746_ DTLGL 751_ FLREG 756_ SASTE 761_ VLRTE 766_ AEQCK 771_ NLELK 776_ DLLPY 781_ GFAIH 786_ HAGMT 791_ RVDRT 796_ LVEDL 801_ FADKH 806_ IQVLV 811_ STATL 816_ AWGVN 821_ LPAHT 826_ VIIKG 831_ TQVYS 836_ PEKGR 841_ WTELG 846_ ALDIL 851_ QMLGR 856_ AGRPQ 861_ YDTKG 866_ EGILI 871_ TSHGE 876_ LQYYL 881_ SLLNQ 886_ QLPIE 891_ SQMVS 896_ KLPDM 901_ LNAEI 906_ VLGNV 911_ QNAKD 916_ AVNWL 921_ GYAYL 926_ YIRML 931_ RSPTL 936_ YGISH 941_ DDLKG 946_ DPLLD 951_ QRRLD 956_ LVHTA 961_ ALMLD 966_ KNNLV 971_ KYDKK 976_ TGNFQ 981_ VTELG 986_ RIASH 991_ YYITN 996_ DTVQT 1001_ YNQLL 1006_ KPTLS 1011_ EIELF 1016_ RVFSL 1021_ SSEFK 1026_ NITVR 1031_ EEEKL 1036_ ELQKL 1041_ LERVP 1046_ IPVKE 1051_ SIEEP 1056_ SAKIN 1061_ VLLQA 1066_ FISQL 1071_ KLEGF 1076_ ALMAD 1081_ MVYVT 1086_ QSAGR 1091_ LMRAI 1096_ FEIVL 1101_ NRGWA 1106_ QLTDK 1111_ TLNLC 1116_ KMIDK 1121_ RMWQS 1126_ MCPLR 1131_ QFRKL 1136_ PEEVV 1141_ KKIEK 1146_ KNFPF 1151_ ERLYD 1156_ LNHNE 1161_ IGELI 1166_ RMPKM 1171_ GKTIH 1176_ KYVHL 1181_ FPKLE 1186_ LSVHL 1191_ QPITR 1196_ STLKV 1201_ ELTIT 1206_ PDFQW 1211_ DEKVH 1216_ GSSEA 1221_ FWILV 1226_ EDVDS 1231_ EVILH 1236_ HEYFL 1241_ LKAKY 1246_ AQDEH 1251_ LITFF 1256_ VPVFE 1261_ PLPPQ 1266_ YFIRV 1271_ VSDRW 1276_ LSCET 1281_ QLPVS 1286_ FRHLI 1291_ LPEKY 1296_ PPPTE 1301_ LLDLQ 1306_ PLPVS 1311_ ALRNS 1316_ AFESL 1321_ YQDKF 1326_ PFFNP 1331_ IQTQV 1336_ FNTVY 1341_ NSDDN 1346_ VFVGA 1351_ PTGSG 1356_ KTICA 1361_ EFAIL 1366_ RMLLQ 1371_ SSEGR 1376_ CVYIT 1381_ PMEAL 1386_ AEQVY 1391_ MDWYE 1396_ KFQDR 1401_ LNKKV 1406_ VLLTG 1411_ ETSTD 1416_ LKLLG 1421_ KGNII 1426_ ISTPE 1431_ KWDIL 1436_ SRRWK 1441_ QRKNV 1446_ QNINL 1451_ FVVDE 1456_ VHLIG 1461_ GENGP 1466_ VLEVI 1471_ CSRMR 1476_ YISSQ 1481_ IERPI 1486_ RIVAL 1491_ SSSLS 1496_ NAKDV 1501_ AHWLG 1506_ CSATS 1511_ TFNFH 1516_ PNVRP 1521_ VPLEL 1526_ HIQGF 1531_ NISHT 1536_ QTRLL 1541_ SMAKP 1546_ VYHAI 1551_ TKHSP 1556_ KKPVI 1561_ VFVPS 1566_ RKQTR 1571_ LTAID 1576_ ILTTC 1581_ AADIQ 1586_ RQRFL 1591_ HCTEK 1596_ DLIPY 1601_ LEKLS 1606_ DSTLK 1611_ ETLLN 1616_ GVGYL 1621_ HEGLS 1626_ PMERR 1631_ LVEQL 1636_ FSSGA 1641_ IQVVV 1646_ ASRSL 1651_ CWGMN 1656_ VAAHL 1661_ VIIMD 1666_ TQYYN 1671_ GKIHA 1676_ YVDYP 1681_ IYDVL 1686_ QMVGH 1691_ ANRPL 1696_ QDDEG 1701_ RCVIM 1706_ CQGSK 1711_ KDFFK 1716_ KFLYE 1721_ PLPVE 1726_ SHLDH 1731_ CMHDH 1736_ FNAEI 1741_ VTKTI 1746_ ENKQD 1751_ AVDYL 1756_ TWTFL 1761_ YRRMT 1766_ QNPNY 1771_ YNLQG 1776_ ISHRH 1781_ LSDHL 1786_ SELVE 1791_ QTLSD 1796_ LEQSK 1801_ CISIE 1806_ DEMDV 1811_ APLNL 1816_ GMIAA 1821_ YYYIN 1826_ YTTIE 1831_ LFSMS 1836_ LNAKT 1841_ KVRGL 1846_ IEIIS 1851_ NAAEY 1856_ ENIPI 1861_ RHHED 1866_ NLLRQ 1871_ LAQKV 1876_ PHKLN 1881_ NPKFN 1886_ DPHVK 1891_ TNLLL 1896_ QAHLS 1901_ RMQLS 1906_ AELQS 1911_ DTEEI 1916_ LSKAI 1921_ RLIQA 1926_ CVDVL 1931_ SSNGW 1936_ LSPAL 1941_ AAMEL 1946_ AQMVT 1951_ QAMWS 1956_ KDSYL 1961_ KQLPH 1966_ FTSEH 1971_ IKRCT 1976_ DKGVE 1981_ SVFDI 1986_ MEMED 1991_ EERNA 1996_ LLQLT 2001_ DSQIA 2006_ DVARF 2011_ CNRYP 2016_ NIELS 2021_ YEVVD 2026_ KDSIR 2031_ SGGPV 2036_ VVLVQ 2041_ LEREE 2046_ EVTGP 2051_ VIAPL 2056_ FPQKR 2061_ EEGWW 2066_ VVIGD 2071_ AKSNS 2076_ LISIK 2081_ RLTLQ 2086_ QKAKV 2091_ KLDFV 2096_ APATG 2101_ AHNYT 2106_ LYFMS 2111_ DAYMG 2116_ CDQEY 2121_ KFSVD 2126_ VKEAE 2131_TDSDS
1: Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome (PubMed:35241646). Plays a role in pre-mRNA splicing as a core component of precatalytic, catalytic and postcatalytic spliceosomal complexes (PubMed:28502770, PubMed:28781166, PubMed:29301961, PubMed:29360106, PubMed:29361316, PubMed:30315277, PubMed:30705154, PubMed:30728453). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in spliceosome assembly, activation and disassembly. Mediates changes in the dynamic network of RNA-RNA interactions in the spliceosome