TIP41-like protein (Putative MAPK-activating protein PM10) (Type 2A-interacting protein) (TIP)
1_MMIHG 6_ FQSSH 11_ RDFCF 16_ GPWKL 21_ TASKT 26_ HIMKS 31_ ADVEK 36_ LADEL 41_ HMPSL 46_ PEMMF 51_ GDNVL 56_ RIQHG 61_ SGFGI 66_ EFNAT 71_ DALRC 76_ VNNYQ 81_ GMLKV 86_ ACAEE 91_ WQESR 96_ TEGEH 101_ SKEVI 106_ KPYDW 111_ TYTTD 116_ YKGTL 121_ LGESL 126_ KLKVV 131_ PTTDH 136_ IDTEK 141_ LKARE 146_ QIKFF 151_ EEVLL 156_ FEDEL 161_ HDHGV 166_ SSLSV 171_ KIRVM 176_ PSSFF 181_ LLLRF 186_ FLRID 191_ GVLIR 196_ MNDTR 201_ LYHEA 206_ DKTYM 211_ LREYT 216_ SRESK 221_ ISSLM 226_ HVPPS 231_ LFTEP 236_ NEISQ 241_ YLPIK 246_ EAVCE 251_ KLIFP 256_ ERIDP 261_ NPADS 266_QKSTQ
1: May be a allosteric regulator of serine/threonine-protein phosphatase 2A (PP2A). Isoform 1 inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. Acts as a negative regulator of serine/threonine-protein phosphatase 4 probably by inhibiting the formation of the active PPP4C:PPP4R2 complex; the function is proposed to implicate it in DNA damage response by promoting H2AX phosphorylated on Ser-140 (gamma-H2AX). May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair