Ribosomal protein S6 kinase alpha-4 (S6K-alpha-4) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 4) (Nuclear mitogen- and stress-activated protein kinase 2) (Ribosomal protein kinase B) (RSKB)
1_MGDED 6_ DDESC 11_ AVELR 16_ ITEAN 21_ LTGHE 26_ EKVSV 31_ ENFEL 36_ LKVLG 41_ TGAYG 46_ KVFLV 51_ RKAGG 56_ HDAGK 61_ LYAMK 66_ VLRKA 71_ ALVQR 76_ AKTQE 81_ HTRTE 86_ RSVLE 91_ LVRQA 96_ PFLVT 101_ LHYAF 106_ QTDAK 111_ LHLIL 116_ DYVSG 121_ GEMFT 126_ HLYQR 131_ QYFKE 136_ AEVRV 141_ YGGEI 146_ VLALE 151_ HLHKL 156_ GIIYR 161_ DLKLE 166_ NVLLD 171_ SEGHI 176_ VLTDF 181_ GLSKE 186_ FLTEE 191_ KERTF 196_ SFCGT 201_ IEYMA 206_ PEIIR 211_ SKTGH 216_ GKAVD 221_ WWSLG 226_ ILLFE 231_ LLTGA 236_ SPFTL 241_ EGERN 246_ TQAEV 251_ SRRIL 256_ KCSPP 261_ FPPRI 266_ GPVAQ 271_ DLLQR 276_ LLCKD 281_ PKKRL 286_ GAGPQ 291_ GAQEV 296_ RNHPF 301_ FQGLD 306_ WVALA 311_ ARKIP 316_ APFRP 321_ QIRSE 326_ LDVGN 331_ FAEEF 336_ TRLEP 341_ VYSPP 346_ GSPPP 351_ GDPRI 356_ FQGYS 361_ FVAPS 366_ ILFDH 371_ NNAVM 376_ TDGLE 381_ APGAG 386_ DRPGR 391_ AAVAR 396_ SAMMQ 401_ DSPFF 406_ QQYEL 411_ DLREP 416_ ALGQG 421_ SFSVC 426_ RRCRQ 431_ RQSGQ 436_ EFAVK 441_ ILSRR 446_ LEANT 451_ QREVA 456_ ALRLC 461_ QSHPN 466_ VVNLH 471_ EVHHD 476_ QLHTY 481_ LVLEL 486_ LRGGE 491_ LLEHI 496_ RKKRH 501_ FSESE 506_ ASQIL 511_ RSLVS 516_ AVSFM 521_ HEEAG 526_ VVHRD 531_ LKPEN 536_ ILYAD 541_ DTPGA 546_ PVKII 551_ DFGFA 556_ RLRPQ 561_ SPGVP 566_ MQTPC 571_ FTLQY 576_ AAPEL 581_ LAQQG 586_ YDESC 591_ DLWSL 596_ GVILY 601_ MMLSG 606_ QVPFQ 611_ GASGQ 616_ GGQSQ 621_ AAEIM 626_ CKIRE 631_ GRFSL 636_ DGEAW 641_ QGVSE 646_ EAKEL 651_ VRGLL 656_ TVDPA 661_ KRLKL 666_ EGLRG 671_ SSWLQ 676_ DGSAR 681_ SSPPL 686_ RTPDV 691_ LESSG 696_ PAVRS 701_ GLNAT 706_ FMAFN 711_ RGKRE 716_ GFFLK 721_ SVENA 726_ PLAKR 731_ RKQKL 736_ RSATA 741_ SRRGS 746_ PAPAN 751_ PGRAP 756_ VASKG 761_ APRRA 766_NGPLP
1: Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors