Protein phosphatase 1B (EC 3.1.3.16) (Protein phosphatase 2C isoform beta) (PP2C-beta)
1_MGAFL 6_ DKPKT 11_ EKHNA 16_ HGAGN 21_ GLRYG 26_ LSSMQ 31_ GWRVE 36_ MEDAH 41_ TAVVG 46_ IPHGL 51_ EDWSF 56_ FAVYD 61_ GHAGS 66_ RVANY 71_ CSTHL 76_ LEHIT 81_ TNEDF 86_ RAAGK 91_ SGSAL 96_ ELSVE 101_ NVKNG 106_ IRTGF 111_ LKIDE 116_ YMRNF 121_ SDLRN 126_ GMDRS 131_ GSTAV 136_ GVMIS 141_ PKHIY 146_ FINCG 151_ DSRAV 156_ LYRNG 161_ QVCFS 166_ TQDHK 171_ PCNPR 176_ EKERI 181_ QNAGG 186_ SVMIQ 191_ RVNGS 196_ LAVSR 201_ ALGDY 206_ DYKCV 211_ DGKGP 216_ TEQLV 221_ SPEPE 226_ VYEIL 231_ RAEED 236_ EFIIL 241_ ACDGI 246_ WDVMS 251_ NEELC 256_ EYVKS 261_ RLEVS 266_ DDLEN 271_ VCNWV 276_ VDTCL 281_ HKGSR 286_ DNMSI 291_ VLVCF 296_ SNAPK 301_ VSDEA 306_ VKKDS 311_ ELDKH 316_ LESRV 321_ EEIME 326_ KSGEE 331_ GMPDL 336_ AHVMR 341_ ILSAE 346_ NIPNL 351_ PPGGG 356_ LAGKR 361_ NVIEA 366_ VYSRL 371_ NPHRE 376_ SDGAS 381_ DEAEE 386_ SGSQG 391_ KLVEA 396_ LRQMR 401_ INHRG 406_ NYRQL 411_ LEEML 416_ TSYRL 421_ AKVEG 426_ EESPA 431_ EPAAT 436_ ATSSN 441_ SDAGN 446_ PVTMQ 451_ ESHTE 456_ SESGL 461_ AELDS 466_ SNEDA 471_GTKMS
1: Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at 'Ser-172'. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB