Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (Protein kinase PKL12) (TGF-beta-stimulated factor 1) (TSF-1) (Tyrosine-protein kinase STK16) (EC 2.7.10.2) (hPSK)
1_MGHAL 6_ CVCSR 11_ GTVII 16_ DNKRY 21_ LFIQK 26_ LGEGG 31_ FSYVD 36_ LVEGL 41_ HDGHF 46_ YALKR 51_ ILCHE 56_ QQDRE 61_ EAQRE 66_ ADMHR 71_ LFNHP 76_ NILRL 81_ VAYCL 86_ RERGA 91_ KHEAW 96_ LLLPF 101_ FKRGT 106_ LWNEI 111_ ERLKD 116_ KGNFL 121_ TEDQI 126_ LWLLL 131_ GICRG 136_ LEAIH 141_ AKGYA 146_ HRDLK 151_ PTNIL 156_ LGDEG 161_ QPVLM 166_ DLGSM 171_ NQACI 176_ HVEGS 181_ RQALT 186_ LQDWA 191_ AQRCT 196_ ISYRA 201_ PELFS 206_ VQSHC 211_ VIDER 216_ TDVWS 221_ LGCVL 226_ YAMMF 231_ GEGPY 236_ DMVFQ 241_ KGDSV 246_ ALAVQ 251_ NQLSI 256_ PQSPR 261_ HSSAL 266_ RQLLN 271_ SMMTV 276_ DPHQR 281_ PHIPL 286_ LLSQL 291_ EALQP 296_PAPGQ
1: Membrane-associated protein kinase that phosphorylates on serine and threonine residues. In vitro substrates include DRG1, ENO1 and EIF4EBP1. Also autophosphorylates. May be involved in secretory vesicle trafficking or intracellular signaling. May have a role in regulating stromal-epithelial interactions that occur during ductal morphogenesis in the mammary gland. May be involved in TGF-beta signaling. Able to autophosphorylate on Tyr residue; it is however unclear whether it has tyrosine-protein kinase toward other proteins