Solute carrier family 22 member 3 (Extraneuronal monoamine transporter) (EMT) (Organic cation transporter 3)
1_MPSFD 6_ EALQR 11_ VGEFG 16_ RFQRR 21_ VFLLL 26_ CLTGV 31_ TFAFL 36_ FVGVV 41_ FLGTQ 46_ PDHYW 51_ CRGPS 56_ AAALA 61_ ERCGW 66_ SPEEE 71_ WNRTA 76_ PASRG 81_ PEPPE 86_ RRGRC 91_ QRYLL 96_ EAAND 101_ SASAT 106_ SALSC 111_ ADPLA 116_ AFPNR 121_ SAPLV 126_ PCRGG 131_ WRYAQ 136_ AHSTI 141_ VSEFD 146_ LVCVN 151_ AWMLD 156_ LTQAI 161_ LNLGF 166_ LTGAF 171_ TLGYA 176_ ADRYG 181_ RIVIY 186_ LLSCL 191_ GVGVT 196_ GVVVA 201_ FAPNF 206_ PVFVI 211_ FRFLQ 216_ GVFGK 221_ GTWMT 226_ CYVIV 231_ TEIVG 236_ SKQRR 241_ IVGIV 246_ IQMFF 251_ TLGII 256_ ILPGI 261_ AYFIP 266_ NWQGI 271_ QLAIT 276_ LPSFL 281_ FLLYY 286_ WVVPE 291_ SPRWL 296_ ITRKK 301_ GDKAL 306_ QILRR 311_ IAKCN 316_ GKYLS 321_ SNYSE 326_ ITVTD 331_ EEVSN 336_ PSFLD 341_ LVRTP 346_ QMRKC 351_ TLILM 356_ FAWFT 361_ SAVVY 366_ QGLVM 371_ RLGII 376_ GGNLY 381_ IDFFI 386_ SGVVE 391_ LPGAL 396_ LILLT 401_ IERLG 406_ RRLPF 411_ AASNI 416_ VAGVA 421_ CLVTA 426_ FLPEG 431_ IAWLR 436_ TTVAT 441_ LGRLG 446_ ITMAF 451_ EIVYL 456_ VNSEL 461_ YPTTL 466_ RNFGV 471_ SLCSG 476_ LCDFG 481_ GIIAP 486_ FLLFR 491_ LAAVW 496_ LELPL 501_ IIFGI 506_ LASIC 511_ GGLVM 516_ LLPET 521_ KGIAL 526_ PETVD 531_ DVEKL 536_ GSPHS 541_ CKCGR 546_ NKKTP 551_VSRSH
1: Electrogenic voltage-dependent transporter that mediates the transport of a variety of organic cations such as endogenous bioactive amines, cationic drugs and xenobiotics (PubMed:10196521, PubMed:10966924, PubMed:12538837, PubMed:17460754, PubMed:20858707). Cation cellular uptake or release is driven by the electrochemical potential, i.e. membrane potential and concentration gradient (PubMed:10966924). Functions as a Na(+)- and Cl(-)-independent, bidirectional uniporter (PubMed:12538837). Implicated in monoamine neurotransmitters uptake such as dopamine, adrenaline/epinephrine, noradrenaline/norepinephrine, histamine, serotonin and tyramine, thereby supporting a role in homeostatic regulation of aminergic neurotransmission in the brain (PubMed:10196521, PubMed:16581093, PubMed:20858707). Transports dopaminergic neuromodulators cyclo(his-pro) and salsolinol with low efficiency (PubMed:17460754). May be involved in the uptake and disposition of cationic compounds by renal clearance from the blood flow (PubMed:10966924). May contribute to regulate the transport of cationic compounds in testis across the blood-testis-barrier (Probable). Mediates the transport of polyamine spermidine and putrescine (By similarity). Mediates the bidirectional transport of polyamine agmatine (PubMed:12538837). Also transports guanidine (PubMed:10966924). May also mediate intracellular transport of organic cations, thereby playing a role in amine metabolism and intracellular signaling (By similarity)