Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1) (Transformation-sensitive protein p120) (p120) (Wasabi receptor)
1_MKRSL 6_ RKMWR 11_ PGEKK 16_ EPQGV 21_ VYEDV 26_ PDDTE 31_ DFKES 36_ LKVVF 41_ EGSAY 46_ GLQNF 51_ NKQKK 56_ LKRCD 61_ DMDTF 66_ FLHYA 71_ AAEGQ 76_ IELME 81_ KITRD 86_ SSLEV 91_ LHEMD 96_ DYGNT 101_ PLHCA 106_ VEKNQ 111_ IESVK 116_ FLLSR 121_ GANPN 126_ LRNFN 131_ MMAPL 136_ HIAVQ 141_ GMNNE 146_ VMKVL 151_ LEHRT 156_ IDVNL 161_ EGENG 166_ NTAVI 171_ IACTT 176_ NNSEA 181_ LQILL 186_ KKGAK 191_ PCKSN 196_ KWGCF 201_ PIHQA 206_ AFSGS 211_ KECME 216_ IILRF 221_ GEEHG 226_ YSRQL 231_ HINFM 236_ NNGKA 241_ TPLHL 246_ AVQNG 251_ DLEMI 256_ KMCLD 261_ NGAQI 266_ DPVEK 271_ GRCTA 276_ IHFAA 281_ TQGAT 286_ EIVKL 291_ MISSY 296_ SGSVD 301_ IVNTT 306_ DGCHE 311_ TMLHR 316_ ASLFD 321_ HHELA 326_ DYLIS 331_ VGADI 336_ NKIDS 341_ EGRSP 346_ LILAT 351_ ASASW 356_ NIVNL 361_ LLSKG 366_ AQVDI 371_ KDNFG 376_ RNFLH 381_ LTVQQ 386_ PYGLK 391_ NLRPE 396_ FMQMQ 401_ QIKEL 406_ VMDED 411_ NDGCT 416_ PLHYA 421_ CRQGG 426_ PGSVN 431_ NLLGF 436_ NVSIH 441_ SKSKD 446_ KKSPL 451_ HFAAS 456_ YGRIN 461_ TCQRL 466_ LQDIS 471_ DTRLL 476_ NEGDL 481_ HGMTP 486_ LHLAA 491_ KNGHD 496_ KVVQL 501_ LLKKG 506_ ALFLS 511_ DHNGW 516_ TALHH 521_ ASMGG 526_ YTQTM 531_ KVILD 536_ TNLKC 541_ TDRLD 546_ EDGNT 551_ ALHFA 556_ AREGH 561_ AKAVA 566_ LLLSH 571_ NADIV 576_ LNKQQ 581_ ASFLH 586_ LALHN 591_ KRKEV 596_ VLTII 601_ RSKRW 606_ DECLK 611_ IFSHN 616_ SPGNK 621_ CPITE 626_ MIEYL 631_ PECMK 636_ VLLDF 641_ CMLHS 646_ TEDKS 651_ CRDYY 656_ IEYNF 661_ KYLQC 666_ PLEFT 671_ KKTPT 676_ QDVIY 681_ EPLTA 686_ LNAMV 691_ QNNRI 696_ ELLNH 701_ PVCKE 706_ YLLMK 711_ WLAYG 716_ FRAHM 721_ MNLGS 726_ YCLGL 731_ IPMTI 736_ LVVNI 741_ KPGMA 746_ FNSTG 751_ IINET 756_ SDHSE 761_ ILDTT 766_ NSYLI 771_ KTCMI 776_ LVFLS 781_ SIFGY 786_ CKEAG 791_ QIFQQ 796_ KRNYF 801_ MDISN 806_ VLEWI 811_ IYTTG 816_ IIFVL 821_ PLFVE 826_ IPAHL 831_ QWQCG 836_ AIAVY 841_ FYWMN 846_ FLLYL 851_ QRFEN 856_ CGIFI 861_ VMLEV 866_ ILKTL 871_ LRSTV 876_ VFIFL 881_ LLAFG 886_ LSFYI 891_ LLNLQ 896_ DPFSS 901_ PLLSI 906_ IQTFS 911_ MMLGD 916_ INYRE 921_ SFLEP 926_ YLRNE 931_ LAHPV 936_ LSFAQ 941_ LVSFT 946_ IFVPI 951_ VLMNL 956_ LIGLA 961_ VGDIA 966_ EVQKH 971_ ASLKR 976_ IAMQV 981_ ELHTS 986_ LEKKL 991_ PLWFL 996_ RKVDQ 1001_ KSTIV 1006_ YPNKP 1011_ RSGGM 1016_ LFHIF 1021_ CFLFC 1026_ TGEIR 1031_ QEIPN 1036_ ADKSL 1041_ EMEIL 1046_ KQKYR 1051_ LKDLT 1056_ FLLEK 1061_ QHELI 1066_ KLIIQ 1071_ KMEII 1076_ SETED 1081_ DDSHC 1086_ SFQDR 1091_ FKKEQ 1096_ MEQRN 1101_ SRWNT 1106_ VLRAV 1111_KAKTH
1: Ligand-activated Ca(2+)-permeable, nonselective cation channel involved in pain detection and possibly also in cold perception, oxygen concentration perception, cough, itch, and inner ear function (PubMed:17259981, PubMed:21195050, PubMed:21873995, PubMed:23199233, PubMed:25389312, PubMed:33152265). Has a relatively high Ca(2+) selectivity, with a preference for divalent over monovalent cations (Ca(2+) > Ba(2+) > Mg(2+) > NH4(+) > Li(+) > K(+)), the influx of cation into the cytoplasm leads to membrane depolarization (PubMed:19202543, PubMed:21195050). Has a central role in the pain response to endogenous inflammatory mediators, such as bradykinin and to a diverse array of irritants. Activated by a large variety of structurally unrelated electrophilic and non-electrophilic chemical compounds, such as allylthiocyanate (AITC) from mustard oil or wasabi, cinnamaldehyde, diallyl disulfide (DADS) from garlic, and acrolein, an environmental irritant (PubMed:20547126, PubMed:25389312, PubMed:27241698, PubMed:30878828). Electrophilic ligands activate TRPA1 by interacting with critical N-terminal Cys residues in a covalent manner (PubMed:17164327, PubMed:27241698, PubMed:31866091, PubMed:32641835). Non-electrophile agonists bind at distinct sites in the transmembrane domain to promote channel activation (PubMed:33152265). Also acts as an ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana (PubMed:25389312). May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds (By similarity)