Transcription elongation factor A protein 3 (Transcription elongation factor S-II protein 3) (Transcription elongation factor TFIIS.h)
1_MGQEE 6_ ELLRI 11_ AKKLE 16_ KMVAR 21_ KNTEG 26_ ALDLL 31_ KKLHS 36_ CQMSI 41_ QLLQT 46_ TRIGV 51_ AVNGV 56_ RKHCS 61_ DKEVV 66_ SLAKV 71_ LIKNW 76_ KRLLD 81_ SPGPP 86_ KGEKG 91_ EEREK 96_ AKKKE 101_ KGLEC 106_ SDWKP 111_ EAGLS 116_ PPRKK 121_ REDPK 126_ TRRDS 131_ VDSKS 136_ SASSS 141_ PKRPS 146_ VERSN 151_ SSKSK 156_ AESPK 161_ TPSSP 166_ LTPTF 171_ ASSMC 176_ LLAPC 181_ YLTGD 186_ SVRDK 191_ CVEML 196_ SAALK 201_ ADDDY 206_ KDYGV 211_ NCDKM 216_ ASEIE 221_ DHIYQ 226_ ELKST 231_ DMKYR 236_ NRVRS 241_ RISNL 246_ KDPRN 251_ PGLRR 256_ NVLSG 261_ AISAG 266_ LIAKM 271_ TAEEM 276_ ASDEL 281_ RELRN 286_ AMTQE 291_ AIREH 296_ QMAKT 301_ GGTTT 306_ DLFQC 311_ SKCKK 316_ KNCTY 321_ NQVQT 326_ RSADE 331_ PMTTF 336_ VLCNE 341_CGNRW
1: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus