DNA repair protein RAD51 homolog 4 (R51H3) (RAD51 homolog D) (RAD51-like protein 3) (TRAD)
1_MGVLR 6_ VGLCP 11_ GLTEE 16_ MIQLL 21_ RSHRI 26_ KTVVD 31_ LVSAD 36_ LEEVA 41_ QKCGL 46_ SYKAL 51_ VALRR 56_ VLLAQ 61_ FSAFP 66_ VNGAD 71_ LYEEL 76_ KTSTA 81_ ILSTG 86_ IGSLD 91_ KLLDA 96_ GLYTG 101_ EVTEI 106_ VGGPG 111_ SGKTQ 116_ VCLCM 121_ AANVA 126_ HGLQQ 131_ NVLYV 136_ DSNGG 141_ LTASR 146_ LLQLL 151_ QAKTQ 156_ DEEEQ 161_ AEALR 166_ RIQVV 171_ HAFDI 176_ FQMLD 181_ VLQEL 186_ RGTVA 191_ QQVTG 196_ SSGTV 201_ KVVVV 206_ DSVTA 211_ VVSPL 216_ LGGQQ 221_ REGLA 226_ LMMQL 231_ ARELK 236_ TLARD 241_ LGMAV 246_ VVTNH 251_ ITRDR 256_ DSGRL 261_ KPALG 266_ RSWSF 271_ VPSTR 276_ ILLDT 281_ IEGAG 286_ ASGGR 291_ RMACL 296_ AKSSR 301_ QPTGF 306_ QEMVD 311_ IGTWG 316_ TSEQS 321_ATLQG
1: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Bind to single-stranded DNA (ssDNA) and has DNA-dependent ATPase activity. Part of the RAD51 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Involved in telomere maintenance. The BCDX2 subcomplex XRCC2:RAD51D can stimulate Holliday junction resolution by BLM