Renin receptor (ATPase H(+)-transporting lysosomal accessory protein 2) (ATPase H(+)-transporting lysosomal-interacting protein 2) (ER-localized type I transmembrane adapter) (Embryonic liver differentiation factor 10) (N14F) (Renin/prorenin receptor) (Vacuolar ATP synthase membrane sector-associated protein M8-9) (ATP6M8-9) (V-ATPase M8.9 subunit) [Cleaved into: Renin receptor N-terminal fragment; Renin receptor C-terminal fragment]
1_MAVFV 6_ VLLAL 11_ VAGVL 16_ GNEFS 21_ ILKSP 26_ GSVVF 31_ RNGNW 36_ PIPGE 41_ RIPDV 46_ AALSM 51_ GFSVK 56_ EDLSW 61_ PGLAV 66_ GNLFH 71_ RPRAT 76_ VMVMV 81_ KGVNK 86_ LALPP 91_ GSVIS 96_ YPLEN 101_ AVPFS 106_ LDSVA 111_ NSIHS 116_ LFSEE 121_ TPVVL 126_ QLAPS 131_ EERVY 136_ MVGKA 141_ NSVFE 146_ DLSVT 151_ LRQLR 156_ NRLFQ 161_ ENSVL 166_ SSLPL 171_ NSLSR 176_ NNEVD 181_ LLFLS 186_ ELQVL 191_ HDISS 196_ LLSRH 201_ KHLAK 206_ DHSPD 211_ LYSLE 216_ LAGLD 221_ EIGKR 226_ YGEDS 231_ EQFRD 236_ ASKIL 241_ VDALQ 246_ KFADD 251_ MYSLY 256_ GGNAV 261_ VELVT 266_ VKSFD 271_ TSLIR 276_ KTRTI 281_ LEAKQ 286_ AKNPA 291_ SPYNL 296_ AYKYN 301_ FEYSV 306_ VFNMV 311_ LWIMI 316_ ALALA 321_ VIITS 326_ YNIWN 331_ MDPGY 336_ DSIIY 341_RMTNQ
1: Multifunctional protein which functions as a renin, prorenin cellular receptor and is involved in the assembly of the lysosomal proton-transporting V-type ATPase (V-ATPase) and the acidification of the endo-lysosomal system (PubMed:12045255, PubMed:29127204, PubMed:30374053, PubMed:32276428). May mediate renin-dependent cellular responses by activating ERK1 and ERK2 (PubMed:12045255). By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, may also play a role in the renin-angiotensin system (RAS) (PubMed:12045255). Through its function in V-type ATPase (v-ATPase) assembly and acidification of the lysosome it regulates protein degradation and may control different signaling pathways important for proper brain development, synapse morphology and synaptic transmission (By similarity)