Protein phosphatase 1 regulatory subunit 15A (Growth arrest and DNA damage-inducible protein GADD34) (Myeloid differentiation primary response protein MyD116 homolog)
1_MAPGQ 6_ APHQA 11_ TPWRD 16_ AHPFF 21_ LLSPV 26_ MGLLS 31_ RAWSR 36_ LRGLG 41_ PLEPW 46_ LVEAV 51_ KGAAL 56_ VEAGL 61_ EGEAR 66_ TPLAI 71_ PHTPW 76_ GRRPE 81_ EEAED 86_ SGGPG 91_ EDRET 96_ LGLKT 101_ SSSLP 106_ EAWGL 111_ LDDDD 116_ GMYGE 121_ REATS 126_ VPRGQ 131_ GSQFA 136_ DGQRA 141_ PLSPS 146_ LLIRT 151_ LQGSD 156_ KNPGE 161_ EKAEE 166_ EGVAE 171_ EEGVN 176_ KFSYP 181_ PSHRE 186_ CCPAV 191_ EEEDD 196_ EEAVK 201_ KEAHR 206_ TSTSA 211_ LSPGS 216_ KPSTW 221_ VSCPG 226_ EEENQ 231_ ATEDK 236_ RTERS 241_ KGARK 246_ TSVSP 251_ RSSGS 256_ DPRSW 261_ EYRSG 266_ EASEE 271_ KEEKA 276_ HKETG 281_ KGEAA 286_ PGPQS 291_ SAPAQ 296_ RPQLK 301_ SWWCQ 306_ PSDEE 311_ EGEVK 316_ ALGAA 321_ EKDGE 326_ AECPP 331_ CIPPP 336_ SAFLK 341_ AWVYW 346_ PGEDT 351_ EEEED 356_ EEEDE 361_ DSDSG 366_ SDEEE 371_ GEAEA 376_ SSSTP 381_ ATGVF 386_ LKSWV 391_ YQPGE 396_ DTEEE 401_ EDEDS 406_ DTGSA 411_ EDERE 416_ AETSA 421_ STPPA 426_ SAFLK 431_ AWVYR 436_ PGEDT 441_ EEEED 446_ EDVDS 451_ EDKED 456_ DSEAA 461_ LGEAE 466_ SDPHP 471_ SHPDQ 476_ RAHFR 481_ GWGYR 486_ PGKET 491_ EEEEA 496_ AEDWG 501_ EAEPC 506_ PFRVA 511_ IYVPG 516_ EKPPP 521_ PWAPP 526_ RLPLR 531_ LQRRL 536_ KRPET 541_ PTHDP 546_ DPETP 551_ LKARK 556_ VRFSE 561_ KVTVH 566_ FLAVW 571_ AGPAQ 576_ AARQG 581_ PWEQL 586_ ARDRS 591_ RFARR 596_ ITQAQ 601_ EELSP 606_ CLTPA 611_ ARARA 616_ WARLR 621_ NPPLA 626_ PIPAL 631_ TQTLP 636_ SSSVP 641_ SSPVQ 646_ TTPLS 651_ QAVAT 656_ PSRSS 661_ AAAAA 666_ALDLS
1: Recruits the serine/threonine-protein phosphatase PPP1CA to prevents excessive phosphorylation of the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress (PubMed:26095357, PubMed:26742780). Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1 (PubMed:14718519). May promote apoptosis by inducing p53/TP53 phosphorylation on 'Ser-15' (PubMed:14635196). Plays an essential role in autophagy by tuning translation during starvation, thus enabling lysosomal biogenesis and a sustained autophagic flux (PubMed:32978159). Also acts a viral restriction factor by attenuating HIV-1 replication (PubMed:31778897). Mechanistically, mediates the inhibition of HIV-1 TAR RNA-mediated translation (PubMed:31778897)
2: (Microbial infection) Promotes enterovirus 71 replication by mediating the internal ribosome entry site (IRES) activity of viral 5'-UTR