Breast cancer anti-estrogen resistance protein 3 (Novel SH2-containing protein 2) (SH2 domain-containing protein 3B)
1_MAAGK 6_ FASLP 11_ RNMPV 16_ NHQFP 21_ LASSM 26_ DLLSS 31_ RSPLA 36_ EHRPD 41_ AYQDV 46_ SIHGT 51_ LPRKK 56_ KGPPP 61_ IRSCD 66_ DFSHM 71_ GTLPH 76_ SKSPR 81_ QNSPV 86_ TQDGI 91_ QESPW 96_ QDRHG 101_ ETFTF 106_ RDPHL 111_ LDPTV 116_ EYVKF 121_ SKERH 126_ IMDRT 131_ PEKLK 136_ KELEE 141_ ELLLS 146_ SEDLR 151_ SHAWY 156_ HGRIP 161_ RQVSE 166_ NLVQR 171_ DGDFL 176_ VRDSL 181_ SSPGN 186_ FVLTC 191_ QWKNL 196_ AQHFK 201_ INRTV 206_ LRLSE 211_ AYSRV 216_ QYQFE 221_ MESFD 226_ SIPGL 231_ VRCYV 236_ GNRRP 241_ ISQQS 246_ GAIIF 251_ QPINR 256_ TVPLR 261_ CLEEH 266_ YGTSP 271_ GQARE 276_ GSLTK 281_ GRPDV 286_ AKRLS 291_ LTMGG 296_ VQARE 301_ QNLPR 306_ GNLLR 311_ NKEKS 316_ GSQPA 321_ CLDHM 326_ QDRRA 331_ LSLKA 336_ HQSES 341_ YLPIG 346_ CKLPP 351_ QSSGV 356_ DTSPC 361_ PNSPV 366_ FRTGS 371_ EPALS 376_ PAVVR 381_ RVSSD 386_ ARAGE 391_ ALRGS 396_ DSQLC 401_ PKPPP 406_ KPCKV 411_ PFLKV 416_ PSSPS 421_ AWLNS 426_ EANYC 431_ ELNPA 436_ FATGC 441_ GRGAK 446_ LPSCA 451_ QGSHT 456_ ELLTA 461_ KQNEA 466_ PGPRN 471_ SGVNY 476_ LILDD 481_ DDRER 486_ PWEPA 491_ AAQME 496_ KGQWD 501_ KGEFV 506_ TPLLE 511_ TVSSF 516_ RPNEF 521_ ESKFL 526_ PPENK 531_ PLETA 536_ MLKRA 541_ KELFT 546_ NNDPK 551_ VIAQH 556_ VLSMD 561_ CRVAR 566_ ILGVS 571_ EEMRR 576_ NMGVS 581_ SGLEL 586_ ITLPH 591_ GHQLR 596_ LDIIE 601_ RHNTM 606_ AIGIA 611_ VDILG 616_ CTGTL 621_ EDRAA 626_ TLSKI 631_ IQVAV 636_ ELKDS 641_ MGDLY 646_ SFSAL 651_ MKALE 656_ MPQIT 661_ RLEKT 666_ WTALR 671_ HQYTQ 676_ TAILY 681_ EKQLK 686_ PFSKL 691_ LHEGR 696_ ESTCV 701_ PPNNV 706_ SVPLL 711_ MPLVT 716_ LMERQ 721_ AVTFE 726_ GTDMW 731_ EKNDQ 736_ SCEIM 741_ LNHLA 746_ TARFM 751_ AEAAD 756_ SYRMN 761_ AERIL 766_ AGFQP 771_ DEEMN 776_ EICKT 781_ EFQMR 786_ LLWGS 791_ KGAQV 796_ NQTER 801_ YEKFN 806_ QILTA 811_ LSRKL 816_EPPPV
1: Acts as an adapter protein downstream of several growth factor receptors to promote cell proliferation, migration, and redistribution of actin fibers (PubMed:24216110). Specifically involved in INS/insulin signaling pathway by mediating MAPK1/ERK2-MAPK3/ERK1 activation and DNA synthesis (PubMed:24216110). Promotes insulin-mediated membrane ruffling (By similarity). In response to vasoconstrictor peptide EDN1, involved in the activation of RAP1 downstream of PTK2B via interaction with phosphorylated BCAR1 (PubMed:19086031). Inhibits cell migration and invasion via regulation of TGFB-mediated matrix digestion, actin filament rearrangement, and inhibition of invadopodia activity (By similarity). May inhibit TGFB-SMAD signaling, via facilitating BCAR1 and SMAD2 and/or SMAD3 interaction (By similarity). Regulates EGF-induced DNA synthesis (PubMed:18722344). Required for the maintenance of ocular lens morphology and structural integrity, potentially via regulation of focal adhesion complex signaling (By similarity). Acts upstream of PTPRA to regulate the localization of BCAR1 and PTPRA to focal adhesions, via regulation of SRC-mediated phosphorylation of PTPRA (By similarity). Positively regulates integrin-induced tyrosine phosphorylation of BCAR1 (By similarity). Acts as a guanine nucleotide exchange factor (GEF) for small GTPases RALA, RAP1A and RRAS (By similarity). However, in a contrasting study, lacks GEF activity towards RAP1 (PubMed:22081014)