Eukaryotic translation initiation factor 3 subunit G (eIF3g) (Eukaryotic translation initiation factor 3 RNA-binding subunit) (eIF-3 RNA-binding subunit) (Eukaryotic translation initiation factor 3 subunit 4) (eIF-3-delta) (eIF3 p42) (eIF3 p44)
1_MPTGD 6_ FDSKP 11_ SWADQ 16_ VEEEG 21_ EDDKC 26_ VTSEL 31_ LKGIP 36_ LATGD 41_ TSPEP 46_ ELLPG 51_ APLPP 56_ PKEVI 61_ NGNIK 66_ TVTEY 71_ KIDED 76_ GKKFK 81_ IVRTF 86_ RIETR 91_ KASKA 96_ VARRK 101_ NWKKF 106_ GNSEF 111_ DPPGP 116_ NVATT 121_ TVSDD 126_ VSMTF 131_ ITSKE 136_ DLNCQ 141_ EEEDP 146_ MNKLK 151_ GQKIV 156_ SCRIC 161_ KGDHW 166_ TTRCP 171_ YKDTL 176_ GPMQK 181_ ELAEQ 186_ LGLST 191_ GEKEK 196_ LPGEL 201_ EPVQA 206_ TQNKT 211_ GKYVP 216_ PSLRD 221_ GASRR 226_ GESMQ 231_ PNRRA 236_ DDNAT 241_ IRVTN 246_ LSEDT 251_ RETDL 256_ QELFR 261_ PFGSI 266_ SRIYL 271_ AKDKT 276_ TGQSK 281_ GFAFI 286_ SFHRR 291_ EDAAR 296_ AIAGV 301_ SGFGY 306_ DHLIL 311_NVEWA
1: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). This subunit can bind 18S rRNA
2: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426)