Eukaryotic translation initiation factor 3 subunit J (eIF3j) (Eukaryotic translation initiation factor 3 subunit 1) (eIF-3-alpha) (eIF3 p35)
1_MAAAA 6_ AAAGD 11_ SDSWD 16_ ADAFS 21_ VEDPV 26_ RKVGG 31_ GGTAG 36_ GDRWE 41_ GEDED 46_ EDVKD 51_ NWDDD 56_ DDEKK 61_ EEAEV 66_ KPEVK 71_ ISEKK 76_ KIAEK 81_ IKEKE 86_ RQQKK 91_ RQEEI 96_ KKRLE 101_ EPEEP 106_ KVLTP 111_ EEQLA 116_ DKLRL 121_ KKLQE 126_ ESDLE 131_ LAKET 136_ FGVNN 141_ AVYGI 146_ DAMNP 151_ SSRDD 156_ FTEFG 161_ KLLKD 166_ KITQY 171_ EKSLY 176_ YASFL 181_ EVLVR 186_ DVCIS 191_ LEIDD 196_ LKKIT 201_ NSLTV 206_ LCSEK 211_ QKQEK 216_ QSKAK 221_ KKKKG 226_ VVPGG 231_ GLKAT 236_ MKDDL 241_ ADYGG 246_ YDGGY 251_VQDYE
1: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773)