Carbonyl reductase [NADPH] 3 (EC 1.1.1.184) (NADPH-dependent carbonyl reductase 3) (Quinone reductase CBR3) (EC 1.6.5.10) (Short chain dehydrogenase/reductase family 21C member 2)
1_MSSCS 6_ RVALV 11_ TGANR 16_ GIGLA 21_ IAREL 26_ CRQFS 31_ GDVVL 36_ TARDV 41_ ARGQA 46_ AVQQL 51_ QAEGL 56_ SPRFH 61_ QLDID 66_ DLQSI 71_ RALRD 76_ FLRKE 81_ YGGLN 86_ VLVNN 91_ AAVAF 96_ KSDDP 101_ MPFDI 106_ KAEMT 111_ LKTNF 116_ FATRN 121_ MCNEL 126_ LPIMK 131_ PHGRV 136_ VNISS 141_ LQCLR 146_ AFENC 151_ SEDLQ 156_ ERFHS 161_ ETLTE 166_ GDLVD 171_ LMKKF 176_ VEDTK 181_ NEVHE 186_ REGWP 191_ NSPYG 196_ VSKLG 201_ VTVLS 206_ RILAR 211_ RLDEK 216_ RKADR 221_ ILVNA 226_ CCPGP 231_ VKTDM 236_ DGKDS 241_ IRTVE 246_ EGAET 251_ PVYLA 256_ LLPPD 261_ ATEPQ 266_ GQLVH 271_DKVVQ
1: Catalyzes the NADPH-dependent reduction of carbonyl compounds to their corresponding alcohols (PubMed:18493841). Has low NADPH-dependent oxidoreductase activity. Acts on several orthoquinones, acts as well on non-quinone compounds, such as isatin or on the anticancer drug oracin (PubMed:15537833, PubMed:18493841, PubMed:19841672). Best substrates for CBR3 is 1,2- naphthoquinone, hence could play a role in protection against cytotoxicity of exogenous quinones (PubMed:19841672). Exerts activity toward ortho-quinones but not paraquinones. No endogenous substrate for CBR3 except isatin has been identified (PubMed:19841672)