26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) (Gankyrin) (p28(GANK))
1_MEGCV 6_ SNLMV 11_ CNLAY 16_ SGKLE 21_ ELKES 26_ ILADK 31_ SLATR 36_ TDQDS 41_ RTALH 46_ WACSA 51_ GHTEI 56_ VEFLL 61_ QLGVP 66_ VNDKD 71_ DAGWS 76_ PLHIA 81_ ASAGR 86_ DEIVK 91_ ALLGK 96_ GAQVN 101_ AVNQN 106_ GCTPL 111_ HYAAS 116_ KNRHE 121_ IAVML 126_ LEGGA 131_ NPDAK 136_ DHYEA 141_ TAMHR 146_ AAAKG 151_ NLKMI 156_ HILLY 161_ YKAST 166_ NIQDT 171_ EGNTP 176_ LHLAC 181_ DEERV 186_ EEAKL 191_ LVSQG 196_ ASIYI 201_ ENKEE 206_ KTPLQ 211_ VAKGG 216_ LGLIL 221_KRMVE
1: Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module. Independently of the proteasome, regulates EGF-induced AKT activation through inhibition of the RHOA/ROCK/PTEN pathway, leading to prolonged AKT activation. Plays an important role in RAS-induced tumorigenesis
2: Acts as an proto-oncoprotein by being involved in negative regulation of tumor suppressors RB1 and p53/TP53. Overexpression is leading to phosphorylation of RB1 and proteasomal degradation of RB1. Regulates CDK4-mediated phosphorylation of RB1 by competing with CDKN2A for binding with CDK4. Facilitates binding of MDM2 to p53/TP53 and the mono- and polyubiquitination of p53/TP53 by MDM2 suggesting a function in targeting the TP53:MDM2 complex to the 26S proteasome. Involved in p53-independent apoptosis. Involved in regulation of NF-kappa-B by retaining it in the cytoplasm. Binds to the NF-kappa-B component RELA and accelerates its XPO1/CRM1-mediated nuclear export