Calcium and integrin-binding family member 2 (Kinase-interacting protein 2) (KIP 2)
1_MGNKQ 6_ TIFTE 11_ EQLDN 16_ YQDCT 21_ FFNKK 26_ DILKL 31_ HSRFY 36_ ELAPN 41_ LVPMD 46_ YRKSP 51_ IVHVP 56_ MSLII 61_ QMPEL 66_ RENPF 71_ KERIV 76_ AAFSE 81_ DGEGN 86_ LTFND 91_ FVDMF 96_ SVLCE 101_ SAPRE 106_ LKANY 111_ AFKIY 116_ DFNTD 121_ NFICK 126_ EDLEL 131_ TLARL 136_ TKSEL 141_ DEEEV 146_ VLVCD 151_ KVIEE 156_ ADLDG 161_ DGKLG 166_ FADFE 171_ DMIAK 176_ APDFL 181_STFHI
1: Calcium- and integrin-binding protein that plays a role in intracellular calcium homeostasis (By similarity). Acts as an auxiliary subunit of the sensory mechanoelectrical transduction (MET) channel in hair cells (By similarity). Essential for mechanoelectrical transduction (MET) currents in auditory hair cells and thereby required for hearing (By similarity). Regulates the function of hair cell mechanotransduction by controlling the distribution of transmembrane channel-like proteins TMC1 and TMC2, and by regulating the function of the MET channels in hair cells (By similarity). Required for the maintenance of auditory hair cell stereocilia bundle morphology and function and for hair-cell survival in the cochlea (By similarity). Critical for proper photoreceptor cell maintenance and function (By similarity). Plays a role in intracellular calcium homeostasis by decreasing ATP-induced calcium release (PubMed:23023331, PubMed:26173970, PubMed:26426422)