Lathosterol oxidase (EC 1.14.19.20) (C-5 sterol desaturase) (Delta(7)-sterol 5-desaturase) (Delta(7)-sterol C5(6)-desaturase) (Lathosterol 5-desaturase) (Sterol-C5-desaturase)
1_MDLVL 6_ RVADY 11_ YFFTP 16_ YVYPA 21_ TWPED 26_ DIFRQ 31_ AISLL 36_ IVTNV 41_ GAYIL 46_ YFFCA 51_ TLSYY 56_ FVFDH 61_ ALMKH 66_ PQFLK 71_ NQVRR 76_ EIKFT 81_ VQALP 86_ WISIL 91_ TVALF 96_ LLEIR 101_ GYSKL 106_ HDDLG 111_ EFPYG 116_ LFELV 121_ VSIIS 126_ FLFFT 131_ DMFIY 136_ WIHRG 141_ LHHRL 146_ VYKRL 151_ HKPHH 156_ IWKIP 161_ TPFAS 166_ HAFHP 171_ IDGFL 176_ QSLPY 181_ HIYPF 186_ IFPLH 191_ KVVYL 196_ SLYIL 201_ VNIWT 206_ ISIHD 211_ GDFRV 216_ PQILQ 221_ PFING 226_ SAHHT 231_ DHHMF 236_ FDYNY 241_ GQYFT 246_ LWDRI 251_ GGSFK 256_ NPSSF 261_ EGKGP 266_ LSYVK 271_ EMTEG 276_ KRSSH 281_ SGNGC 286_ KNEKL 291_FNGEF
1: Catalyzes the penultimate step of the biosynthesis of cholesterol, the dehydrogenation of lathosterol into 7-dehydrocholesterol (7-DHC). Cholesterol is the major sterol component in mammalian membranes and a precursor for bile acid and steroid hormone synthesis (PubMed:10786622, PubMed:38297129). In addition to its essential role in cholesterol biosynthesis, it also indirectly regulates ferroptosis through the production of 7-DHC. By diverting the spread of damage caused by peroxyl radicals from the phospholipid components to its sterol nucleus, 7-DHC prevents this form of cell death (PubMed:38297129, PubMed:38297130)