Isocitrate dehydrogenase [NADP] cytoplasmic (IDH) (IDH1) (EC 1.1.1.42) (Cytosolic NADP-isocitrate dehydrogenase) (IDPc) (NADP(+)-specific ICDH) (Oxalosuccinate decarboxylase)
1_MSKKI 6_ SGGSV 11_ VEMQG 16_ DEMTR 21_ IIWEL 26_ IKEKL 31_ IFPYV 36_ ELDLH 41_ SYDLG 46_ IENRD 51_ ATNDQ 56_ VTKDA 61_ AEAIK 66_ KHNVG 71_ VKCAT 76_ ITPDE 81_ KRVEE 86_ FKLKQ 91_ MWKSP 96_ NGTIR 101_ NILGG 106_ TVFRE 111_ AIICK 116_ NIPRL 121_ VSGWV 126_ KPIII 131_ GRHAY 136_ GDQYR 141_ ATDFV 146_ VPGPG 151_ KVEIT 156_ YTPSD 161_ GTQKV 166_ TYLVH 171_ NFEEG 176_ GGVAM 181_ GMYNQ 186_ DKSIE 191_ DFAHS 196_ SFQMA 201_ LSKGW 206_ PLYLS 211_ TKNTI 216_ LKKYD 221_ GRFKD 226_ IFQEI 231_ YDKQY 236_ KSQFE 241_ AQKIW 246_ YEHRL 251_ IDDMV 256_ AQAMK 261_ SEGGF 266_ IWACK 271_ NYDGD 276_ VQSDS 281_ VAQGY 286_ GSLGM 291_ MTSVL 296_ VCPDG 301_ KTVEA 306_ EAAHG 311_ TVTRH 316_ YRMYQ 321_ KGQET 326_ STNPI 331_ ASIFA 336_ WTRGL 341_ AHRAK 346_ LDNNK 351_ ELAFF 356_ ANALE 361_ EVSIE 366_ TIEAG 371_ FMTKD 376_ LAACI 381_ KGLPN 386_ VQRSD 391_ YLNTF 396_ EFMDK 401_ LGENL 406_KIKLA
1: Catalyzes the NADP(+)-dependent oxidative decarboxylation of isocitrate (D-threo-isocitrate) to 2-ketoglutarate (2-oxoglutarate), which is required by other enzymes such as the phytanoyl-CoA dioxygenase (PubMed:10521434, PubMed:19935646). Plays a critical role in the generation of NADPH, an important cofactor in many biosynthesis pathways (PubMed:10521434). May act as a corneal epithelial crystallin and may be involved in maintaining corneal epithelial transparency (By similarity)