Serine hydrolase RBBP9 (EC 3.-.-.-) (B5T-overexpressed gene protein) (Protein BOG) (Retinoblastoma-binding protein 10) (RBBP-10) (Retinoblastoma-binding protein 9) (RBBP-9)
1_MASPS 6_ KAVIV 11_ PGNGG 16_ GDVTT 21_ HGWYG 26_ WVKKE 31_ LEKIP 36_ GFQCL 41_ AKNMP 46_ DPITA 51_ RESIW 56_ LPFME 61_ TELHC 66_ DEKTI 71_ IIGHS 76_ SGAIA 81_ AMRYA 86_ ETHRV 91_ YAIVL 96_ VSAYT 101_ SDLGD 106_ ENERA 111_ SGYFT 116_ RPWQW 121_ EKIKA 126_ NCPYI 131_ VQFGS 136_ TDDPF 141_ LPWKE 146_ QQEVA 151_ DRLET 156_ KLHKF 161_ TDCGH 166_ FQNTE 171_ FHELI 176_ TVVKS 181_LLKVP
1: Serine hydrolase (Probable) (PubMed:32196348). Catalyzes the hydrolytic activation of amino acid ester of the antiviral prodrug valacyclovir to its corresponding active drug, acyclovir (PubMed:32196348). May negatively regulate basal or autocrine TGF-beta signaling by suppressing SMAD2-SMAD3 phosphorylation (PubMed:20080647). May play a role in the transformation process due to its capacity to confer resistance to the growth-inhibitory effects of TGF-beta through interaction with RB1 and the subsequent displacement of E2F1 (PubMed:9697699)