Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein)
1_MPLFT 6_ ANPFE 11_ QDVEK 16_ ATNEY 21_ NTTED 26_ WSLIM 31_ DICDK 36_ VGSTP 41_ NGAKD 46_ CLKAI 51_ MKRVN 56_ HKVPH 61_ VALQA 66_ LTLLG 71_ ACVAN 76_ CGKIF 81_ HLEVC 86_ SRDFA 91_ TEVRA 96_ VIKNK 101_ AHPKV 106_ CEKLK 111_ SLMVE 116_ WSEEF 121_ QKDPQ 126_ FSLIS 131_ ATIKS 136_ MKEEG 141_ ITFPP 146_ AGSQT 151_ VSAAA 156_ KNGTS 161_ SNKNK 166_ EDEDI 171_ AKAIE 176_ LSLQE 181_ QKQQH 186_ TETKS 191_ LYPSS 196_ EIQLN 201_ NKVAR 206_ KVRAL 211_ YDFEA 216_ VEDNE 221_ LTFKH 226_ GEIII 231_ VLDDS 236_ DANWW 241_ KGENH 246_ RGIGL 251_ FPSNF 256_ VTTNL 261_ NIETE 266_ AAAVD 271_ KLNVI 276_ DDDVE 281_ EIKKS 286_ EPEPV 291_ YIDED 296_ KMDRA 301_ LQVLQ 306_ SIDPT 311_ DSKPD 316_ SQDLL 321_ DLEDI 326_ CQQMG 331_ PMIDE 336_ KLEEI 341_ DRKHS 346_ ELSEL 351_ NVKVL 356_ EALEL 361_ YNKLV 366_ NEAPV 371_ YSVYS 376_ KLHPP 381_ AHYPP 386_ ASSGV 391_ PMQTY 396_ PVQSH 401_ GGNYM 406_ GQSIH 411_ QVTVA 416_ QSYSL 421_ GPDQI 426_ GPLRS 431_ LPPNV 436_ NSSVT 441_ AQPAQ 446_ TSYLS 451_ TGQDT 456_ VSNPT 461_ YMNQN 466_ SNLQS 471_ ATGTT 476_ AYTQQ 481_ MGMSV 486_ DMSSY 491_ QNTTS 496_ NLPQL 501_ AGFPV 506_ TVPAH 511_ PVAQQ 516_HTNYH
1: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as a sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity)